A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

Details

Serval ID
serval:BIB_8DF2816EA432
Type
Article: article from journal or magazin.
Collection
Publications
Title
A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Pearse M., Wu L., Egerton M., Wilson A., Shortman K., Scollay R.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1989
Volume
86
Number
5
Pages
1614-1618
Language
english
Abstract
Precursors of all T-lineage cells are found in the population of thymocytes that lacks the CD4 and CD8 surface markers. These "double-negative" thymocytes are heterogeneous and can be divided into discrete subpopulations based on their expression of other surface markers. We have determined the relative maturity of these subpopulations based on the extent of rearrangement and expression of their T-cell receptor genes, their cell cycle status, and their thymus reconstitution capacity. Within the subpopulation of double negatives expressing high levels of the heat-stable antigen, the additional markers phagocytic glycoprotein 1 (Pgp-1) and interleukin 2 receptor (IL-2R) can be used to define the sequence IL-2R- Pgp-1+----IL-2R+ Pgp-1-----IL-2R- Pgp-1-, which occurs before the expression of CD4 and CD8. Transient expression of the IL-2R marks an important developmental point in the sequence just prior to a burst of cell proliferation and a loss of thymus reconstitution ability. The earliest cells in this sequence are already partially rearranged for genes in the C beta 1 region. IL-2R expression marks a second wave of T-cell antigen receptor of beta-chain gene rearrangement and the initiation of T-cell antigen receptor alpha- and beta-chain gene expression.
Keywords
Animals, Antigens, CD8, Antigens, Differentiation, T-Lymphocyte/genetics, Gene Rearrangement, T-Lymphocyte, Interleukin-2/metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, RNA, Messenger/genetics, Receptors, Interleukin-2/genetics, T-Lymphocytes/classification, T-Lymphocytes/immunology, Transcription, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
11/04/2013 10:33
Last modification date
20/08/2019 14:51
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