Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors

Details

Serval ID
serval:BIB_8DD0ADB3E9B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors
Journal
Bone Marrow Transplant
Author(s)
Caillat-Zucman S., Le Deist F., Haddad E., Gannage M., Dal Cortivo L., Jabado N., Hacein-Bey-Abina S., Blanche S., Casanova J. L., Fischer A., Cavazzana-Calvo M.
ISSN
0268-3369 (Print)
ISSN-L
0268-3369
Publication state
Published
Issued date
06/2004
Volume
33
Number
11
Pages
1089-95
Language
english
Notes
Caillat-Zucman, S
Le Deist, F
Haddad, E
Gannage, M
Dal Cortivo, L
Jabado, N
Hacein-Bey-Abina, S
Blanche, S
Casanova, J-L
Fischer, A
Cavazzana-Calvo, M
eng
Comparative Study
Research Support, Non-U.S. Gov't
England
Bone Marrow Transplant. 2004 Jun;33(11):1089-95. doi: 10.1038/sj.bmt.1704510.
Abstract
SUMMARY: Hematological inherited diseases can be cured by hematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical sibling donor (MSD), but the outcome of unrelated donors (URD) or haploidentical donors (HMD) has been a cause of concern. In all, 94 children affected with inherited diseases underwent HSCT at a single center using MSD (group A, n=31), URD (group B, n=23) or HMD (group C, n=40). There was no difference in the rate of engraftment or in the incidence of grades III-IV acute graft-versus-host disease (GVHD) between the groups. Survival rate was 80.6% in group A, 62.5% in group B and 47.5% in group C (P=0.023). In group B, survival rate was 73.7% in the subgroup with zero or one class I mismatch, and 25% in the subgroup with two or more class I mismatches (P=0.04). In group C, survival rate was 83.3% in the 9/10-identical subgroup, 64.3% in the seven or 8/10 subgroup, and 25% in the five or 6/10 subgroup (P=0.0007). Thus, engraftment, incidence of GVHD and survival are similar in recipients of grafts from MSD, URD with 0-1 class I-mismatch, or HMD with at least 7/10 HLA matches. The low success of HSCT using more disparate donors suggests reserving them for patients with very poor prognosis.
Keywords
Adolescent, Child, Child, Preschool, Genetic Diseases, Inborn/complications/mortality/*therapy, Genotype, Graft Survival/immunology, Graft vs Host Disease/immunology, Haplotypes, *Hematopoietic Stem Cell Transplantation/adverse effects/mortality/statistics &, numerical data, Histocompatibility/*genetics, *Histocompatibility Testing, Humans, Infant, Opportunistic Infections/immunology, Survival Analysis, Tissue Donors, Transplantation, Homologous, Transplantation, Isogeneic, Treatment Outcome
Pubmed
Create date
10/03/2022 11:43
Last modification date
11/03/2022 7:33
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