Conidiobolus pachyzygosporus invasive pulmonary infection in a patient with acute myeloid leukemia: case report and review of the literature.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_8DBE542AD411
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Conidiobolus pachyzygosporus invasive pulmonary infection in a patient with acute myeloid leukemia: case report and review of the literature.
Journal
BMC infectious diseases
Author(s)
Stavropoulou E., Coste A.T., Beigelman-Aubry C., Letovanec I., Spertini O., Lovis A., Krueger T., Burger R., Bochud P.Y., Lamoth F.
ISSN
1471-2334 (Electronic)
ISSN-L
1471-2334
Publication state
Published
Issued date
22/07/2020
Peer-reviewed
Oui
Volume
20
Number
1
Pages
527
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Conidiobolus spp. (mainly C. coronatus) are the causal agents of rhino-facial conidiobolomycosis, a limited soft tissue infection, which is essentially observed in immunocompetent individuals from tropical areas. Rare cases of invasive conidiobolomycosis due to C. coronatus or other species (C.incongruus, C.lamprauges) have been reported in immunocompromised patients. We report here the first case of invasive pulmonary fungal infection due to Conidiobolus pachyzygosporus in a Swiss patient with onco-haematologic malignancy.
A 71 year-old female was admitted in a Swiss hospital for induction chemotherapy of acute myeloid leukemia. A chest CT performed during the neutropenic phase identified three well-circumscribed lung lesions consistent with invasive fungal infection, along with a positive 1,3-beta-d-glucan assay in serum. A transbronchial biopsy of the lung lesions revealed large occasionally septate hyphae. A Conidiobolus spp. was detected by direct 18S rDNA in the tissue biopsy and subsequently identified at species level as C. pachyzygosporus by 28S rDNA sequencing. The infection was cured after isavuconazole therapy, recovery of the immune system and surgical resection of lung lesions.
This is the first description of C. pachyzygosporus as human pathogen and second case report of invasive conidiobolomycosis from a European country.
Keywords
Conidiobolomycolosis, Enthomophthoramycosis, Entomophthorales, Invasive fungal infections
Pubmed
Open Access
Yes
Create date
27/07/2020 8:18
Last modification date
11/09/2020 6:22
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