Multimodal neural correlates of childhood psychopathology

Details

Serval ID
serval:BIB_8D8353DB7C44
Type
Autre: use this type when nothing else fits.
Collection
Publications
Title
Multimodal neural correlates of childhood psychopathology
Author(s)
Kebets Valeria, Piguet Camille, Chen Jianzhong, Ooi Leon Qi Rong, Kirschner Matthias, Siffredi Vanessa, Misic Bratislav, Yeo B.T. Thomas, Bernhardt Boris C.
Issued date
03/03/2023
Language
english
Abstract
Complex structural and functional changes occurring in typical and atypical development
necessitate multidimensional approaches to better understand the risk of developing
psychopathology. Here, we simultaneously examined structural and functional brain network
patterns in relation to dimensions of psychopathology in the Adolescent Brain Cognitive
Development dataset. Several components were identified, recapitulating the psychopathology
hierarchy, with the general psychopathology (p) factor explaining most covariance with
multimodal imaging features, while the internalizing, externalizing, and neurodevelopmental
dimensions were each associated with distinct morphological and functional connectivity
signatures. Connectivity signatures associated with the p factor and neurodevelopmental
dimensions followed the sensory-to-transmodal axis of cortical organization, which is related
to the emergence of complex cognition and risk for psychopathology. Results were consistent
in two separate data subsamples, supporting generalizability, and robust to variations in
analytical parameters. Our findings help in better understanding biological mechanisms
underpinning dimensions of psychopathology, and could provide brain-based vulnerability
markers.
Create date
23/11/2023 11:46
Last modification date
10/01/2024 17:33
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