KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity.

Details

Serval ID
serval:BIB_8D7D3E68F6EB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Vuillemin X., Juhas M., Masseron A., Bechtel-Grosch U., Tiziani S., Mancini S., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
22/07/2020
Peer-reviewed
Oui
Volume
64
Number
8
Pages
e00321-20
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) an association with a sharp reduction of its carbapenemase activity.
Keywords
Anti-Bacterial Agents/pharmacology, Azabicyclo Compounds/pharmacology, Bacterial Proteins/genetics, Ceftazidime/pharmacology, Drug Combinations, Drug Resistance, Bacterial, Humans, Klebsiella Infections/drug therapy, Klebsiella pneumoniae/genetics, Microbial Sensitivity Tests, Switzerland, beta-Lactamases/genetics, KPC, Klebsiella pneumoniae, ceftazidime-avibactam
Pubmed
Web of science
Open Access
Yes
Create date
10/06/2020 22:23
Last modification date
06/04/2024 7:24
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