BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients.

Details

Serval ID
serval:BIB_8D70B98824D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients.
Journal
Blood
Author(s)
Erard V., Kim H.W., Corey L., Limaye A., Huang M.L., Myerson D., Davis C., Boeckh M.
ISSN
0006-4971
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
106
Number
3
Pages
1130-1132
Language
english
Abstract
We performed a case-control study to determine the association of BK plasma viremia with hemorrhagic cystitis (HC) in hematopoietic cell transplant (HCT) recipients. Thirty cases of HC (14 of which occurred after platelet engraftment with documented BK viruria [BK-HC]) were compared with matched controls. Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR). BK viremia detected before or during the disease was independently associated with HC (adjusted odds ratio = 30, P < .001); BK viremia was even important before clinical symptoms of HC occurred (odds ratio = 11, P < .001). Cases of HC and BK-HC had a significantly higher peak of BK plasma viral load than controls. BK virus was detected by in situ hybridization in bladder biopsies of 2 cases with severe HC and long-lasting BK viremia. BK virus seems to play a role in the development of HC and quantitative detection of BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.
Keywords
Adolescent, Adult, BK Virus/isolation & purification, Case-Control Studies, Child, Cystitis/etiology, Cystitis/virology, DNA, Viral/blood, Female, Hematopoietic Stem Cell Transplantation/adverse effects, Hemorrhage, Humans, Male, Middle Aged, Odds Ratio, Polymerase Chain Reaction, Polyomavirus Infections/complications, Transplantation, Homologous, Tumor Virus Infections/complications, Viral Load/methods, Viremia/complications
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2010 17:50
Last modification date
20/08/2019 15:51
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