Chest pulse-wave velocity: a novel approach to assess arterial stiffness.
Details
Serval ID
serval:BIB_8D174D9A17B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chest pulse-wave velocity: a novel approach to assess arterial stiffness.
Journal
IEEE Transactions On Bio-medical Engineering
ISSN
1558-2531 (Electronic)
ISSN-L
0018-9294
Publication state
Published
Issued date
2011
Volume
58
Number
1
Pages
215-223
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Pulse-wave velocity (PWV) is considered as the gold-standard method to assess arterial stiffness, an independent predictor of cardiovascular morbidity and mortality. Current available devices that measure PWV need to be operated by skilled medical staff, thus, reducing the potential use of PWV in the ambulatory setting. In this paper, we present a new technique allowing continuous, unsupervised measurements of pulse transit times (PTT) in central arteries by means of a chest sensor. This technique relies on measuring the propagation time of pressure pulses from their genesis in the left ventricle to their later arrival at the cutaneous vasculature on the sternum. Combined thoracic impedance cardiography and phonocardiography are used to detect the opening of the aortic valve, from which a pre-ejection period (PEP) value is estimated. Multichannel reflective photoplethysmography at the sternum is used to detect the distal pulse-arrival time (PAT). A PTT value is then calculated as PTT = PAT - PEP. After optimizing the parameters of the chest PTT calculation algorithm on a nine-subject cohort, a prospective validation study involving 31 normo- and hypertensive subjects was performed. 1/chest PTT correlated very well with the COMPLIOR carotid to femoral PWV (r = 0.88, p < 10 (-9)). Finally, an empirical method to map chest PTT values onto chest PWV values is explored.
Keywords
Adult, Aged, Algorithms, Arteries/physiopathology, Blood Pressure/physiology, Cardiography, Impedance/methods, Cohort Studies, Elasticity/physiology, Electrocardiography/methods, Humans, Middle Aged, Photoplethysmography/methods, Signal Processing, Computer-Assisted
Pubmed
Web of science
Create date
21/03/2012 15:53
Last modification date
20/08/2019 15:51