The Endocrinology of Recurrent Pregnancy Loss

Details

Serval ID
serval:BIB_8D1449AEC31B
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Title
The Endocrinology of Recurrent Pregnancy Loss
Title of the book
Recurrent Pregnancy Loss: causes, controversies and treatment
Author(s)
Pluchino Nicola, Bellaminutti Serena, Drakapoulos Panagiotis, Makrigiannakis Antonis, Genazzani Andrea R
Publisher
Taylor & Francis
ISBN
9781138325654
9780429450303
Publication state
Published
Issued date
2020
Chapter
7
Edition
3rd edition
Language
english
Abstract
A randomized control trial of 64 hyperprolactinemic women with Recurrent Pregnancy Loss (RPL) treated with bromocriptine showed a higher incidence of live births, while PRL levels were significantly higher in women who miscarried. Progesterone is essential for successful implantation and maintenance of a normal pregnancy. Therefore, disorders related to inadequate progesterone secretion by the corpus luteum may affect the outcome of the pregnancy. One plausible explanation for the relationship between hypothyroidism and pregnancy loss is luteal phase defect linked to a hypofunctioning thyroid. Untreated hypothyroidism in pregnancy is associated with a greater risk for adverse pregnancy complications, such as miscarriage, premature birth, low birth weight, and detrimental effects on fetal neurocognitive development. Treatment of endometriosis has been shown to be beneficial for future fertility and improved pregnancy outcomes. Studies from in vitro fertilization have documented decreased pregnancy rates that can be improved with gonadotropin-releasing hormone agonist suppression, surgery, or aromatase inhibitor therapy.
Create date
15/09/2023 13:24
Last modification date
27/09/2023 14:41
Usage data