Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging.

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Serval ID
serval:BIB_8CA79D834903
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging.
Journal
Journal of Neurology
Author(s)
Russmann H., Vingerhoets F., Miklossy J., Maeder P., Glatzel M., Aguzzi A., Bogousslavsky J.
ISSN
0340-5354
Publication state
Published
Issued date
03/2005
Peer-reviewed
Oui
Volume
252
Number
3
Pages
338-342
Language
english
Notes
Publication types: Case Reports ; Comparative Study ; Journal Article
Abstract
To investigate a possible relationship between the severity of pathological and radiological lesions in diffusion-weighted MRI (DWI) we compared DWI findings from 6 sequential brain MRI scans with pathological features of numerous tissue blocks of different cortical and subcortical regions in a case of autopsy-proven sporadic CJD. Whereas DWI and pathological examination revealed multifocal, cortical and deep hyperintensities at corresponding localizations, no correlation between the degree of severity of radiologically visible and pathological damage was found.The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem.
Keywords
Cell Death, Creutzfeldt-Jakob Syndrome/pathology, Creutzfeldt-Jakob Syndrome/radiography, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Gliosis/etiology, Humans, Middle Aged, Radiology/methods, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
11/04/2008 9:23
Last modification date
01/10/2019 7:18
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