Aspergillus fumigatus-Related Species in Clinical Practice.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_8CA521F64F9B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aspergillus fumigatus-Related Species in Clinical Practice.
Journal
Frontiers In Microbiology
Author(s)
Lamoth F.
ISSN
1664-302X (Electronic)
ISSN-L
1664-302X
Publication state
Published
Issued date
2016
Volume
7
Pages
683
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Aspergillus fumigatus is the main etiologic agent of invasive aspergillosis (IA). Other Aspergillus species belonging to the section Fumigati (A. fumigatus complex) may occasionally be the cause of IA. These strains are often misidentified, as they cannot be distinguished from A. fumigatus by conventional morphological analysis and sequencing methods. This lack of recognition may have important consequences as these A. fumigatus-related species often display some level of intrinsic resistance to azoles and other antifungal drugs. A. lentulus, A. udagawae, A. viridinutans, and A. thermomutatus (Neosartorya pseudofischeri) have been associated with refractory cases of IA. Microbiologists should be able to suspect the presence of these cryptic species behind a putative A. fumigatus isolate on the basis of some simple characteristics, such as defect in sporulation and/or unusual antifungal susceptibility profile. However, definitive species identification requires specific sequencing analyses of the beta-tubulin or calmodulin genes, which are not available in most laboratories. Multiplex PCR assays or matrix-assisted laser desorption ionization - time-of-flight mass spectrometry (MALDI-TOF MS) gave promising results for rapid and accurate distinction between A. fumigatus and other Aspergillus spp. of the section Fumigati in clinical practice. Improved diagnostic procedures and antifungal susceptibility testing may be helpful for the early detection and management of these particular IA cases.
Pubmed
Web of science
Open Access
Yes
Create date
11/10/2016 16:55
Last modification date
21/08/2019 7:09
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