Plasma angiotensins, renin, and blood pressure during acute renin inhibition by CGP 38 560A in hypertensive patients.

Details

Ressource 1Download: serval:BIB_8C926ADD9296.P001 (1450.08 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_8C926ADD9296
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasma angiotensins, renin, and blood pressure during acute renin inhibition by CGP 38 560A in hypertensive patients.
Journal
American journal of hypertension
Author(s)
Jeunemaître X., Ménard J., Nussberger J., Guyene T.T., Brunner H.R., Corvol P.
ISSN
0895-7061 (Print)
ISSN-L
0895-7061
Publication state
Published
Issued date
11/1989
Peer-reviewed
Oui
Volume
2
Number
11 Pt 1
Pages
819-827
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
The new renin inhibitor CGP 38560A has been shown to block angiotensin (ANG) production in healthy volunteers. In order to determine its potential antihypertensive effect, the compound was administered in a 30-min infusion, in 12 hypertensive patients (mean blood pressure (BP): 112.8 +/- 3.5 mm Hg). These patients were selected for their sensitivity to captopril: a single oral dose of 50 mg captopril lowered their mean BP by 8.8 +/- 2.2 mm Hg after 30 min and by 15.3 +/- 1.5 mm Hg after 90 min. At the end of the renin inhibitor infusion, mean blood pressure decreased by 5.7 +/- 2.2 mm Hg in the six patients infused with the dose of 0.125 mg/kg and by 6.0 +/- 1.8 mm Hg in the six patients infused with 0.250 mg/kg. The fall in blood pressure was correlated to the initial plasma renin activity (PRA) (r = 0.61, P less than .05). A dose-dependent effect was observed on plasma ANG I which fell by 74% with 0.125 mg/kg and by 94% with 0.250 mg/kg. Identical falls were found for plasma ANG II (72% and 94%, respectively) and ANG I and ANG II were well correlated (r = 0.91, P less than .001). The fall in BP was correlated to the fall in plasma ANG I (r = 0.77, P less than .01). The time-course of the BP changes was parallel to the changes in plasma angiotensins, as were the slightly delayed rise and fall in active renin measured by a direct immunoradiometric assay. When measured by the conventional ANG I radioimmunoassay, PRA values indicated a long-lasting inhibition.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult, Angiotensin II/blood, Blood Pressure/drug effects, Captopril/pharmacology, Humans, Hypertension/blood, Hypertension/drug therapy, Hypertension/physiopathology, Middle Aged, Oligopeptides/administration & dosage, Oligopeptides/pharmacology, Oligopeptides/therapeutic use, Renin/antagonists & inhibitors, Renin/blood, Renin-Angiotensin System/drug effects, Renin-Angiotensin System/physiology
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 17:40
Last modification date
01/10/2019 7:18
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