Fat oxidation kinetics during exercise in obese individuals

Details

Serval ID
serval:BIB_8C8A046F5A9D
Type
Inproceedings: an article in a conference proceedings.
Collection
Publications
Title
Fat oxidation kinetics during exercise in obese individuals
Title of the conference
17th annual congress of the ECSS
Author(s)
Lanzi S., Codecasa F., Cornacchia M., Maestrini S., Salvadori A., Brunani A., Malatesta D.
Address
Bruges (BEL)
Publication state
Published
Issued date
2012
Language
english
Abstract
Introduction
An impaired ability to oxidize fat may be a factor in the obesity's aetiology (3). Moreover, the exercise intensity (Fatmax) eliciting the maximal fat oxidation rate (MFO) was lower in obese (O) compared with lean (L) individuals (4). However, difference in fat oxidation rate (FOR) during exercise between O and L remains equivocal and little is known about FORs during high intensities (>60% ) in O compared with L. This study aimed to characterize fat oxidation kinetics over a large range of intensities in L and O.
Methods
12 healthy L [body mass index (BMI): 22.8±0.4] and 16 healthy O men (BMI: 38.9±1.4) performed submaximal incremental test (Incr) to determine whole-body fat oxidation kinetics using indirect calorimetry. After a 15-min resting period (Rest) and 10-min warm-up at 20% of maximal power output (MPO, determined by a maximal incremental test), the power output was increased by 7.5% MPO every 6-min until respiratory exchange ratio reached 1.0. Venous lactate and glucose and plasma concentration of epinephrine (E), norepinephrine (NE), insulin and non-esterified fatty acid (NEFA) were assessed at each step. A mathematical model (SIN) (1), including three variables (dilatation, symmetry, translation), was used to characterize fat oxidation (normalized by fat-free mass) kinetics and to determine Fatmax and MFO.
Results
FOR at Rest and MFO were not significantly different between groups (p≥0.1). FORs were similar from 20-60% (p≥0.1) and significantly lower from 65-85% in O than in L (p≤0.04). Fatmax was significantly lower in O than in L (46.5±2.5 vs 56.7±1.9 % respectively; p=0.005). Fat oxidation kinetics was characterized by similar translation (p=0.2), significantly lower dilatation (p=0.001) and tended to a left-shift symmetry in O compared with L (p=0.09). Plasma E, insulin and NEFA were significantly higher in L compared to O (p≤0.04). There were no significant differences in glucose, lactate and plasma NE between groups (p≥0.2).
Conclusion
The study showed that O presented a lower Fatmax and a lower reliance on fat oxidation at high, but not at moderate, intensities. This may be linked to a: i) higher levels of insulin and lower E concentrations in O, which may induce blunted lipolysis; ii) higher percentage of type II and a lower percentage of type I fibres (5), and iii) decreased mitochondrial content (2), which may reduce FORs at high intensities and Fatmax. These findings may have implications for an appropriate exercise intensity prescription for optimize fat oxidation in O.
References
1. Cheneviere et al. Med Sci Sports Exerc. 2009
2. Holloway et al. Am J Clin Nutr. 2009
3. Kelley et al. Am J Physiol. 1999
4. Perez-Martin et al. Diabetes Metab. 2001
5. Tanner et al. Am J Physiol Endocrinol Metab. 2002
Keywords
Fatmax, maximal fat oxidation, weight management, indirect calorimetry
Create date
07/12/2012 17:09
Last modification date
03/03/2018 19:13
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