Inflammatory caspases in innate immunity and inflammation.

Details

Serval ID
serval:BIB_8C76324367B2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Inflammatory caspases in innate immunity and inflammation.
Journal
Journal of Innate Immunity
Author(s)
Yazdi A.S., Guarda G., D'Ombrain M.C., Drexler S.K.
ISSN
1662-8128[electronic], 1662-811X[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
2
Number
3
Pages
228-237
Language
english
Abstract
Caspases are best known for their role in apoptosis. More recently, they have gained prominence as critical mediators of innate immune responses. The so-called 'inflammatory caspases' include human caspase-1, -4, -5 and -12 and murine caspase-1, -11 and -12. Of these, caspase-1 is best characterized and serves as the prototype for our understanding of the processing, activation and function of inflammatory caspases. Like their apoptotic counterparts, inflammatory caspases are produced as inactive zymogens and require activation to become proteolytically active. Caspase-1 is activated within the inflammasome, a large cytosolic protein complex that is induced by a growing number of endogenous, microbial, chemical or environmental stimuli. The importance of caspase-1 in initiating innate immune responses is demonstrated by its role in cleaving pro-IL-1 beta and pro-IL-18 to their biologically active forms. New functions have also been implicated, as these proteases and the mechanisms underlying their activation and regulation emerge as important mediators of human health and disease.
Keywords
Animals, Apoptosis/immunology, Caspases/immunology, Caspases/metabolism, Gene Expression Regulation, Enzymologic, Humans, Immunity, Innate, Inflammation, Inflammation Mediators/immunology, Inflammation Mediators/metabolism, Mice, Protein Processing, Post-Translational
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2010 12:18
Last modification date
20/08/2019 15:50
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