Immunotherapy in elderly head and neck cancer patients: a systematic review and meta-analysis.

Details

Serval ID
serval:BIB_8C60E4B38ED8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunotherapy in elderly head and neck cancer patients: a systematic review and meta-analysis.
Journal
Frontiers in oncology
Author(s)
Salvestrini V., Caini S., Scricciolo M., Saerens M., Bollen H., Bonomo P., Caparrotti F., Lorini L., Oliva M., Urbanowicz-Nijaki M., Szturz P.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
14
Pages
1395838
Language
english
Notes
Publication types: Systematic Review
Publication Status: epublish
Abstract
Over the past years, there has been a growing interest in the role of immunotherapy in locally advanced (LA) and recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). High-quality data from prospective trials are lacking for the elderly subpopulation. This systematic review and meta-analysis aims to review the efficacy and safety of immunotherapy in older patients.
A systematic literature search was conducted. Randomized clinical trials providing outcome data on a subgroup of elderly (>65 years old) were available for meta-analysis. Primary outcomes of interest were OS and PFS for efficacy analysis.
Seven studies were included in the systematic review and four in the efficacy analysis. The pooled analysis of OS and PFS showed a consistent benefit (HR 0.78 and 0.91, respectively).
Immunotherapy may be an effective and well-tolerated treatment option in the elderly population, but more prospective and randomized data are needed.
PROSPERO (CRD42022333891).
Keywords
elderly, head and neck cancer, immunotherapy, locally advance head and neck cancer, recurrent and metastatic head and neck cancer
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2024 12:05
Last modification date
15/06/2024 7:03
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