Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.

Details

Serval ID
serval:BIB_8C51B9B60D35
Type
Article: article from journal or magazin.
Collection
Publications
Title
Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.
Journal
Journal of Neurology, Neurosurgery, and Psychiatry
Author(s)
Dolan R.J., Bench C.J., Brown R.G., Scott L.C., Friston K.J., Frackowiak R.S.
ISSN
0022-3050 (Print)
ISSN-L
0022-3050
Publication state
Published
Issued date
1992
Volume
55
Number
9
Pages
768-773
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Depression with cognitive impairment, so called depressive pseudodementia, is commonly mistaken for a neurodegenerative dementia. Using positron emission tomography (PET) derived measures of regional cerebral blood flow (rCBF) a cohort of 33 patients with major depression was studied. Ten patients displayed significant and reversible cognitive impairment. The patterns of rCBF of these patients were compared with a cohort of equally depressed non-cognitively impaired depressed patients. In the depressed cognitively impaired patients a profile of rCBF abnormalities was identified consisting of decreases in the left anterior medial prefrontal cortex and increases in the cerebellar vermis. These changes were additional to those seen in depression alone and are distinct from those described in neurodegenerative dementia. The cognitive impairment seen in a proportion of depressed patients would seem to be associated with dysfunction of neural systems distinct from those implicated in depression alone or the neurodegenerative dementias.
Keywords
Bipolar Disorder/psychology, Bipolar Disorder/radionuclide imaging, Blood Flow Velocity/physiology, Brain/blood supply, Brain Mapping, Cerebellum/blood supply, Dementia/psychology, Dementia/radionuclide imaging, Depressive Disorder/psychology, Depressive Disorder/radionuclide imaging, Energy Metabolism/physiology, Factitious Disorders/psychology, Factitious Disorders/radionuclide imaging, Female, Frontal Lobe/blood supply, Humans, Male, Mental Status Schedule, Middle Aged, Oxygen Consumption/physiology, Regional Blood Flow/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Yes
Create date
25/09/2011 16:04
Last modification date
20/08/2019 14:50
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