Successful therapy with mycophenolic acid in a membranous glomerulonephritis due to Kimura disease
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Details

Serval ID
serval:BIB_8C4C901DA823
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Successful therapy with mycophenolic acid in a membranous glomerulonephritis due to Kimura disease
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Journal
Clinical nephrology
Author(s)
Gaillard J., Rotman S., Girardet C., Spertini F.
ISSN
0301-0430 (Print)
ISSN-L
0301-0430
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
88
Number
10
Pages
221-225
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Kimura disease (KD) is a rare inflammatory soft tissue disorder of unknown origin most frequent in Asians, the prevalence of which is growing in Western countries. Painless papules and/or nodules with a predilection for the head and the neck region, lymphadenopathies, parotid gland involvement, eosinophilia, and raised IgE levels are parts of its presentation. Renal involvement with various forms of glomerulonephritis, including membranous nephropathy (MN), can occur and is generally associated with a proteinuria that encompasses nephrotic syndrome. Corticosteroids are the mainstay of treatment of KD-associated glomerulonephritis, but steroids withdrawal is often followed by relapsing nephrotic syndrome. Various immunosuppressive agents have been tested to prolong the remission of KD-associated nephrotic syndrome while tapering steroids, but they are only partly effective or associated with significant complications. To the best of our knowledge, we describe here the first case of KD-related membranous glomerulonephritis with a favorable evolution and a sustained remission of 4 years under prolonged therapy with mycophenolic acid (MPA). MPA and its active metabolite, mycophenolate mofetil (MMF), treatments as supportive therapies to corticosteroids and ACE inhibitors should be further investigated in KD-related membranous nephropathies.
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Create date
01/09/2017 9:18
Last modification date
11/09/2018 10:47
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