Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.
Details
Serval ID
serval:BIB_8C33F301F2E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.
Journal
Intensive care medicine
Working group(s)
STARRT-AKI Investigators
Contributor(s)
Bagshaw S.M., Wald R., Adhikari NKJ, Bellomo R., Dreyfuss D., Du B., Gallagher M.P., Gaudry S., Hoste E.A., Lamontagne F., Joannidis M., Liu K.D., McAuley D.F., McGuinness S.P., Nichol A.D., Ostermann M., Palevsky P.M., Qiu H., Pettilä V., Schneider A.G., Smith O.M., Vaara S.T., Weir M., Bellomo R., Eastwood G.M., Peck L., Young H., Kruger P., Laurie G., Saylor E., Meyer J., Venz E., Wetzig K., French C., McGain F., Mulder J., Fennessy G., Koottayi S., Bates S., Towns M., Morgan R., Tippett A., Udy A., Mason C., Licari E., Gantner D., McClure J., Nichol A., McCracken P., Board J., Martin E., Vallance S., Young M., Vladic C., McGloughlin S., Gattas D., Buhr H., Coles J., Hutch D., Wun J., Cole L., Whitehead C., Lowrey J., Masters K., Gresham R., Campbell V., Gutierrez D., Brailsford J., Forbes L., Murray L., Maguire T., NiChonghaile M., Orford N., Bone A., Elderkin T., Salerno T., Chimunda T., Fletcher J., Broadfield E., Porwal S., Knott C., Boschert C., Smith J., Richardson A., Hill D., Duke G., Oziemski P., Cegarra S., Chan P., Welsh D., Hunter S., Roodenburg O., Dyett J., Kokotsis N., Moser M., Yang X, Padayachee L., Vetro J., Gangopadhyay H., Kaufman M., Ghosh A., Said S., Patel A., Bihari S., Matheson E., Jin X., Shrestha T., Schwartz K., Gallagher M.P., Cross R., Cheung W., Wong H., Kol M., Shah A., Wang A.Y., Endre Z., Bradford C., Janin P., Finfer S., Diel N., Gatward J., Hammond N., Delaney A., Bass F., Yarad E., Buscher H., Reynolds C., Baker N., Joannidis M., Bellmann R., Peer A., Hasslacher J., Koglberger P., Klein S., Zotter K., Brandtner A., Finkenstedt A., Ditlbacher A., Hartig F., Fries D., Bachler M., Schenk B., Wagner M., Eller P., Staudinger T., Tiller E., Schellongowski P., Bojic A., Hoste E.A., Bracke S., De Crop L., Vermeiren D., Thome F., Chiella B., Fendt L., Antunes V., Lafrance J.P., Lamontagne F., D'Aragon F., St-Arnaud C., Mayette M., Carbonnaeu É., Marchand J., Masse M.H., Ladouceur M., Turgeon A.F., Lauzier F., Bellemare D., Francoeur C.L., LeBlanc G., Guilbault G., Grenier S., Cloutier E., Boivin A., Delisle-Thibault C., Giannakouros P., Costerousse O., Cailhier J.F., Carrier F.M., Ghamraoui A., Lebrasseur M., Benettaib F., Salamé M., Boumahni D., Sia Y.T., Naud J.F., Roy I., Stelfox H.T., Ruddell S., Manns B.J., Duggan S., Carney D., Barchard J., Whitlock R.P., Belley-Cote E., Savija N., Sabev A., Campbell T., Creary T., Devereaux K., Brodutch S., Rigatto C., Paunovic B., Mooney O., Glybina A., Harasemiw O., Di Nella M., Harmon J., Mehta N., Lakatos L., Haslam N., Lellouche F., Simon M., Tung Y., Lizotte P., Bourchard P.A., Rochwerg B., Karachi T., Millen T., Muscedere J., Maslove D., Boyd J.G., Sibley S., Drover J., Hunt M., Georgescu I., Wax R., Lenga I., Sridhar K., Steele A., Fusco K., Ghate T., Tolibas M., Robinson H., Weir M.A., Taneja R., Ball I.M., Garg A., Campbell E., Ovsenek A., Bagshaw S.M., van Diepen S., Baig N., Magder S., Yao H., Alam A., Campisi J., MacIntyre E., Rokosh E., Scherr K., Lapinsky S., Mehta S., Shah S., Niven D.J., Stelfox H.T., Ruddell S., Russell M., Jim K., Brown G., Oxtoby K., Hall A., Benoit L., Sokolowski C., Prasad B., Rao J., Giebel S., Kutsogiannis D.J., Thompson P., Thompson T., Cirone R., Kavikondala K., Soth M., Clarke F., Takaoka A., Wald R., Mazer D., Burns K., Friedrich J., Klein D., Sandhu G., Santos M., Khalid I., Hodder J., Dodek P., Ayas N., Alcuaz V., Suen G., Rewa O., Singh G., Norris S., Gibson N., Arias C., Shami A., Pelletier C., Adhikari NKJ, Zahirieh A., Amaral A., Marinoff N., Kaur N., Perez A., Wang J., Haljan G., Condin C., McIntyre L., Gomes B., Porteous R., Watpool I., Hiremath S., Clark E., Herridge M.S., Backhouse F., Wilcox M.E., Walczak K., Ki V., Sharman A., Romano M., Bagshaw S.M., Gibney RTN, Romanovsky A.S., Rewa O., McCoshen L., Baig N., Wood G., Ovakim D., Auld F., Carney G., Duan M., Ji X., Guo D., Qi Z., Lin J., Zhang M., Dong L., Liu J., Liu P., Zhi D., Bai G., Qiu Y., Yang Z., Bai J., Liu Z., Zhuang H., Wang H., Li J., Zhao M., Zhou X., Shi X., Ye B., Liu M., Wu J., Fu Y., Long D., Pan Y., Wang J., Mei H., Zhang S., Wen M., Yang E., Mu S., Li J., Hu T., Qin B., Li M., Wang C., Dong X., Wang K., Wang H., Yang J., Du B., Wang C., Wang D., Li N., Yu Z., Xu S., Yao L., Hou G., Liu Z., Lu L., Lian Y., Wang C., Zhang J., Ding R., Qi G., Wang Q., Wang P., Meng Z., Chen M., Hu X., He X., Zhao S., Hang L., Li R., Qin S., Lu K., Dun S., Liu C., Zhou Q., Chen Z., Mei J., Zhang M., Xu H., Lin J., Shi Q., Fu L., Zeng Q., Ma H., Yan J., Gao L., Liu H., Zhang L., Li H., He X., Fan J., Guo L., Liu Y., Wang X., Sun J., Liu Z., Yang J., Ding L., Sheng L., Liu X., Yan J., Wang Q., Wang Y., Zhao D., Zhao S., Hu C., Li J., Deng F., Qui H., Yang Y., Mo M., Pan C., Wu C., Huang Y., Huang L., Liu A., Pettilä V., Vaara S.T., Korhonen A.M., Törnblom S., Sutinen S., Pettilä L., Heinonen J., Lappi E., Suhonen T., Karlsson S., Hoppu S., Jalkanen V., Kuitunen A., Levoranta M., Långsjö J., Ristimäki S., Malila K., Wootten A., Varila S., Järvisalo M.J., Inkinen O., Kentala S., Leivo K., Haltia P., Dreyfuss D., Ricard J.D., Messika J., Tiagarajah A., Emery M., Dechanet A., Gernez C., Roux D., Martin-Lefevre L., Fiancette M., Vinatier I., Lacherade J.C., Colin G., Lebert C., Azais M.A., Yehia A., Pouplet C., Lagarrigue M.H., Seguin A., Crosby L., Maizel J., Titeca-Beauport D., Combes A., Nieszkowska A., Masi P., Demoule A., Mayaux J., Dres M., Morawiec E., Decalvele M., Demiri S., Faure M., Marios C., Mallet M., Ordon M.A., Morizot L., Cantien M., Pousset F., Gaudry S., Poirson F., Cohen Y., Argaud L., Cour M., Bitker L., Simon M., Hernu R., Baudry T., De La Salle S., Robine A., Sedillot N., Tchenio X., Bouisse C., Roux S., Barbar S.D., Trusson R., Tamion F., Grangé S., Carpentier D., Chevrel G., Ensenyat-Martin L., Marque S., Quenot J.P., Andreu P., Dargent A., Large A., Chudeau N., Landais M., Derrien B., Callahan J.C., Guitton C., Le Moal C., Robert A., Asehnoune K., Cinotti R., Grillot N., Demeure D., Vinsonneau C., Rahmani I., Marzouk M., Dekeyser T., Sejourne C., Verlay M., Thevenin F., Delecolle L., Thevenin D., Souweine B., Coupez E., Adda M., Eraldi J.P., Marchalot A., De Prost N., Dessap A.M., Razazi K., Meziani F., Boisrame-Helms J., Clere-Jehl R., Delabranche X., Kummerlen C., Merdji H., Monnier A., Rabouel Y., Rahmani H., Allam H., Chenaf S., Franja V., Pons B., Carles M., Martino F., Richard R., Zuber B., Lacave G., Lakhal K., Rozec B., Van H.D., Boulet É., Fadel F., Cleophax C., Dufour N., Grant C., Thuong M., Reignier J., Canet E., Nicolet L., Boulain T., Nay M.A., Benzekri D., Barbier F., Bretagnol A., Kamel T., Mathonnet A., Muller G., Skarzynski M., Rossi J., Pradet A., Dos Santos S., Guery A., Muller L., Felix L., Bohé J., Thiéry G., Aissaoui N., Vimpere D., Commeureuc M., Diehl J.L., Guerot E., Liangos O., Wittig M., Zarbock A., Küllmar M., van Waegeningh T., Rosenow N., Nichol A.D., Brickell K., Doran P., Murray P.T., Landoni G., Lembo R., Zangrillo A., Monti G., Tozzi M., Marzaroli M., Lombardi G., Paternoster G., Vitiello M., McGuinness S., Parke R., Butler M., Gilder E., Cowdrey K.A., Wallace S., Hallion J., Woolett M., Neal P., Duffy K., Long S., McArthur C., Simmonds C., Chen Y., McConnochie R., Newby L., Knight D., Henderson S., Mehrtens J., Morgan S., Morris A., Vander Hayden K., Burke T., Bailey M., Freebairn R., Chadwick L., Park P., Rolls C., Thomas L., Buehner U., Williams E., Albrett J., Kirkham S., Jackson C., Browne T., Goodson J., Jackson D., Houghton J., Callender O., Higson V., Keet O., Dominy C., Young P., Hunt A., Judd H., Lawrence C., Olatunji S., Robertson Y., Latimer-Bell C., Hendry D., Mckay-Vucago A., Beehre N., Eden X, Lesona X, Navarra L., Robinson C., Jang R., Junge A., Lambert B., Schneider A.G., Thibault M., Eckert P., Kissling S., Polychronopoulos E., Poli E., Altarelli M., Schnorf M., Mallaird S.A., Heidegger C., Perret A., Montillier P., Sangla F., Neils S., De Watteville A., Phull M.K., George A., Hussain N., Pogreban T., Lobaz S., Daniels A., Cunningham M., Kerr D., Nicholson A., Shanmugasundaram P., Abrams J., Manso K., Hambrook G., McKerrow E., Salva J., Foulkes S., Wise M., Morgan M., Brooks J., Cole J., Davies T.M., Hill H., Thomas E., Vizcaychipi M., Baharlo B., Carungcong J., Costa P., Martins L., Kapoor R., Hazelton T., Moon A., Musselwhite J., Shelley B., McCall P., Ostermann M., Arbane G., Bociek A., Marotti M., Lim R., Campos S., Novellas N.G., Cennamo A., Slack A., Wyncoll D., Camporota L., Sparkes S., Tilley R., Rattray A., Moreland G., Duffy J., McGonigal E., Hopkins P., Finney C., Smith J., Noble H., Watson H., Harris C.L., Clarey E., Corcoran E., Beck J., Howcroft C., Youngs N., Wilby E., Ogg B., Wolverson A., Lee S., Butler S., Okubanjo M., Hindle J., Welters I., Williams K., Johnson E., Patrick-Heselton J., Shaw D., Waugh V., Stewart R., Mwaura E., Wren L., Mew L., Sutherland S.B., Adderley J., Ruddy J., Harkins M., Kaye C., Scott T., Mitchell W., Anderson F., Willox F., Jagannathan V., Clark M., Purv S., Sharman A., Meredith M., Ryan L., Conner L., Peters C., Harvey D., Roshdy A., Collins A., Sim M., Henderson S., Chee N., Pitts S., Bowman K., Dilawershah M., Vamplew L., Howe E., Rogers P., Hernandez C., Prendergast C., Benton J., Rosenberg A., Forni L.G., Grant A., Carvelli P., Raithatha A., Bird S., Richardson M., Needham M., Hirst C., Ball J., Leaver S., Howlett L., Delgado C.C., Farnell-Ward S., Farrah H., Gray G., Joseph G., Robinson F., Tridente A., Harrop C., Shuker K., McLaughlan D., Ramsey J., Meehan S., Rose B.O., Reece-Anthony R., Gurung B., Whitehouse T., Snelson C., Veenith T., Johnston A., Cooper L., Carrera R., Ellis K., Fellows E., Harkett S., Bergin C., Spruce E., Despy L., Goundry S., Dooley N., Mason T., Clark A., Dignam G., Ward G., Attwood B., Parsons P., Mason S., Margarson M., Lord J., McGlone P., Hodgson L.E., Chadbourn I., Gomez R., Margalef J., Pretorius R., Hamshere A., Carter J., Cahill H., Grainger L., Howard K., Forshaw G., Guy Z., Kashani K.B., Albright R.C., Amsbaugh A., Stoltenberg A., Niven A.S., Lynch M., O'Mara A., Naeem S., Sharif S., Goulart J.M., Lynch M., O'Mara A., Naeem S., Sharif S., Goulart J.M., Tolwani A., Lyas C., Latta L., Bihorac A., Hashemighouchani H., Efron P., Ruppert M., Cupka J., Kiley S., Carson J., White P., Omalay G., Brown S., Velez L., zMarceron A., Neyra J.A., Aycinena J.C., Elias M., Ortiz-Soriano V.M., Hauschild C., Dorfman R.
ISSN
1432-1238 (Electronic)
ISSN-L
0342-4642
Publication state
Published
Issued date
11/2023
Peer-reviewed
Oui
Volume
49
Number
11
Pages
1305-1316
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
There is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury (AKI).
We conducted a secondary analysis of the STandard versus Accelerated Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial to compare outcomes among patients who initiated RRT with either continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD). We generated a propensity score for the likelihood of receiving CRRT and used inverse probability of treatment with overlap-weighting to address baseline inter-group differences. The primary outcome was a composite of death or RRT dependence at 90-days after randomization.
We identified 1590 trial participants who initially received CRRT and 606 who initially received IHD. The composite outcome of death or RRT dependence at 90-days occurred in 823 (51.8%) patients who commenced CRRT and 329 (54.3%) patients who commenced IHD (unadjusted odds ratio (OR) 0.90; 95% confidence interval (CI) 0.75-1.09). After balancing baseline characteristics with overlap weighting, initial receipt of CRRT was associated with a lower risk of death or RRT dependence at 90-days compared with initial receipt of IHD (OR 0.81; 95% CI 0.66-0.99). This association was predominantly driven by a lower risk of RRT dependence at 90-days (OR 0.61; 95% CI 0.39-0.94).
In critically ill patients with severe AKI, initiation of CRRT, as compared to IHD, was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days.
We conducted a secondary analysis of the STandard versus Accelerated Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial to compare outcomes among patients who initiated RRT with either continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD). We generated a propensity score for the likelihood of receiving CRRT and used inverse probability of treatment with overlap-weighting to address baseline inter-group differences. The primary outcome was a composite of death or RRT dependence at 90-days after randomization.
We identified 1590 trial participants who initially received CRRT and 606 who initially received IHD. The composite outcome of death or RRT dependence at 90-days occurred in 823 (51.8%) patients who commenced CRRT and 329 (54.3%) patients who commenced IHD (unadjusted odds ratio (OR) 0.90; 95% confidence interval (CI) 0.75-1.09). After balancing baseline characteristics with overlap weighting, initial receipt of CRRT was associated with a lower risk of death or RRT dependence at 90-days compared with initial receipt of IHD (OR 0.81; 95% CI 0.66-0.99). This association was predominantly driven by a lower risk of RRT dependence at 90-days (OR 0.61; 95% CI 0.39-0.94).
In critically ill patients with severe AKI, initiation of CRRT, as compared to IHD, was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days.
Keywords
Humans, Acute Kidney Injury/therapy, Continuous Renal Replacement Therapy, Critical Illness/therapy, Renal Dialysis, Renal Replacement Therapy, Acute kidney injury, Continuous, Intermittent hemodialysis, Modality, Mortality, Randomized trial, Renal-replacement therapy
Pubmed
Web of science
Create date
13/10/2023 9:02
Last modification date
20/01/2024 7:12