Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection.

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State: Public
Version: author
Serval ID
serval:BIB_8C247E0DC00C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection.
Journal
British Journal of Cancer
Author(s)
Clifford G.M., Lise M., Franceschi S., Egger M., Bouchardy C., Korol D., Levi F., Ess S., Jundt G., Wandeler G., Fehr J., Schmid P., Battegay M., Bernasconi E., Cavassini M., Calmy A., Keiser O., Schöni-Affolter F.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Barth J., Battegay M., Bernasconi E., Böni J., Bucher HC., Bürgisser P., Burton-Jeangros C., Calmy A., Cavassini M., Egger M., Elzi L., Fehr J., Flepp M., Francioli P., Furrer H., Fux CA., Gorgievski M., Günthard H., Hasse B., Hirsch HH., Hirschel B., Hösli I., Kahlert C., Kaiser L., Keiser O., Kind C., Klimkait T., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., von Wyl V., Weber R., Yerly S.
ISSN
1532-1827 (Electronic)
ISSN-L
0007-0920
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
106
Number
3
Pages
447-452
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Immunodeficiency and AIDS-related pulmonary infections have been suggested as independent causes of lung cancer among HIV-infected persons, in addition to smoking.
METHODS: A total of 68 lung cancers were identified in the Swiss HIV Cohort Study (SHCS) or through linkage with Swiss Cancer Registries (1985-2010), and were individually matched to 337 controls by centre, gender, HIV-transmission category, age and calendar period. Odds ratios (ORs) were estimated by conditional logistic regression.
RESULTS: Overall, 96.2% of lung cancers and 72.9% of controls were ever smokers, confirming the high prevalence of smoking and its strong association with lung cancer (OR for current vs never=14.4, 95% confidence interval (95% CI): 3.36-62.1). No significant associations were observed between CD4+ cell count and lung cancer, neither when measured within 1 year (OR for <200 vs ≥500=1.21, 95% CI: 0.49-2.96) nor further back in time, before lung cancer diagnosis. Combined antiretroviral therapy was not significantly associated with lung cancer (OR for ever vs never=0.67, 95% CI: 0.29-1.52), and nor was a history of AIDS with (OR=0.49, 95% CI: 0.19-1.28) or without (OR=0.53, 95% CI: 0.24-1.18) pulmonary involvement.
CONCLUSION: Lung cancer in the SHCS does not seem to be clearly associated with immunodeficiency or AIDS-related pulmonary disease, but seems to be attributable to heavy smoking.
Keywords
AIDS-Related Opportunistic Infections/complications, Adult, Aged, CD4 Lymphocyte Count, Case-Control Studies, Cohort Studies, Female, HIV Infections/complications, HIV Infections/immunology, Humans, Immunocompromised Host, Lung Diseases/complications, Lung Neoplasms/epidemiology, Lung Neoplasms/etiology, Male, Middle Aged, Odds Ratio, Prevalence, Smoking/adverse effects, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2012 9:29
Last modification date
20/08/2019 15:50
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