Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial.

Details

Serval ID
serval:BIB_8B74B0A94061
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial.
Journal
Frontiers in oncology
Author(s)
Stelmes J.J., Gregoire V., Poorten V.V., Golusiñski W., Szewczyk M., Jones T., Ansarin M., Broglie M.A., Giger R., Klussmann J.P., Evans M., Bourhis J., Leemans C.R., Spriano G., Dietz A., Hunter K., Zimmermann F., Tinhofer I., Patterson J.M., Quaglini S., Govaerts A.S., Fortpied C., Simon C.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
9
Pages
999
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 "Best of" trial, and highlight the potential of this study to help prioritizing either surgery- or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
Keywords
EORTC 1420, functional outcome, head and neck cancer, organ preservation, oropharyngeal cancer
Pubmed
Web of science
Open Access
Yes
Create date
07/11/2019 23:19
Last modification date
10/04/2020 6:26
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