A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates

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Serval ID
serval:BIB_8B577F93377F
Type
Article: article from journal or magazin.
Collection
Publications
Title
A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates
Journal
Cortex
Author(s)
Rochat Lucien, Billieux Joël, Juillerat Van der Linden Anne-Claude, Annoni Jean-Marie, Zekry Dina, Gold Gabriel, Van der Linden Martial
ISSN
0010-9452
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
49
Number
1
Pages
90-100
Language
english
Abstract
Introduction: Impulsive behaviors are frequently described in brain-damaged patients,
including patients with Alzheimer’s disease (AD). However, few studies have examined
impulsivity changes and associated cognitive impairments in AD and healthy controls.
Consequently, the first aimof this study was to compare patients with mild AD and matched
controls on four dimensions of impulsivity (urgency, lack of premeditation, lack of perseverance,
and sensation seeking) recently highlighted in the literature. The second objective
was to examine the association between impulsivity changes and cognitive performances on
executive/attentional tasks in mild AD and healthy controls.
Methods: Thirty patients with mild AD and 30 matched controls were administered
a battery of tests that assessed executive and attention processes. In addition, informants
of each patient and control completed a short questionnaire designed to assess the
changes on the four dimensions of impulsivity (Rochat et al., 2008).
Results: Patients with mild AD had higher scores than controls on lack of premeditation and
lack of perseverance dimensions of impulsivity, whereas the two groups did not differ on
urgency and sensation seeking. Furthermore, patients showed significant decreased performances
onmeasures of inhibition of prepotent responses, set-shifting, and workingmemory,
as well as higher variability of reaction times (RTs) than matched controls. Regression analyses
computed on the whole sample emphasized that difficulties in inhibition of prepotent
responses significantly predicted higher lack of premeditation, and larger variability of RTs
and set-shifting difficulties significantly predicted higher lack of perseverance, even when
global cognitive functioning, general processing speed, working memory, and age were
controlled for. Urgency and sensation seeking were not associated with any variables.
Keywords
UPPS, Impulsivity, Alzheimer, Executive Functions
Pubmed
Web of science
Create date
10/01/2020 10:31
Last modification date
22/01/2020 10:15
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