Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery.

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Serval ID
serval:BIB_8B49C3C16B37
Type
Article: article from journal or magazin.
Collection
Publications
Title
Therapeutic options to enhance coma arousal after traumatic brain injury: state of the art of current treatments to improve coma recovery.
Journal
British Journal of Neurosurgery
Author(s)
Cossu G.
ISSN
1360-046X (Electronic)
ISSN-L
0268-8697
Publication state
Published
Issued date
2014
Volume
28
Number
2
Pages
187-198
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Traumatic brain injury is a leading cause of death and disability. Optimizing the recovery from coma is a priority in seeking to improve patients' functional outcomes. Standards of care have not been established: pharmacological interventions, right median nerve and sensory stimulation, dorsal column stimulation (DCS), deep brain stimulation, transcranial magnetic stimulation, hyperbaric oxygen therapy and cell transplantation have all been utilized with contrasting results. The aim of this review is to clarify the indications for the various techniques and to guide the clinical practice towards an earlier coma arousal. A systematic bibliographic search was undertaken using the principal search engines (Pubmed, Embase, Ovid and Cochrane databases) to locate the most pertinent studies. Traumatic injury is a highly individualized process, and subsequent impairments are dependent on multiple factors: this heterogeneity influences and determines therapeutic responses to the various interventions.
Keywords
Amantadine/therapeutic use, Arousal, Brain Injuries/complications, Brain Injuries/rehabilitation, Cell Transplantation, Central Nervous System Stimulants/therapeutic use, Coma/etiology, Coma/rehabilitation, Deep Brain Stimulation, Dopamine Agents/therapeutic use, Drug Therapy, Electric Stimulation Therapy, Glasgow Coma Scale, Humans, Hyperbaric Oxygenation, Median Nerve/physiology, Methylphenidate/therapeutic use, Recovery of Function, Spinal Cord/physiology, Transcranial Magnetic Stimulation, Treatment Outcome
Pubmed
Create date
02/12/2014 1:59
Last modification date
27/04/2020 11:24
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