Oral immunization against Helicobacter pylori--a future concept

Details

Serval ID
serval:BIB_8B3CF5659206
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Oral immunization against Helicobacter pylori--a future concept
Journal
Journal of Gastroenterology
Author(s)
Michetti  P.
ISSN
0944-1174 (Print)
Publication state
Published
Issued date
1998
Volume
33 Suppl 10
Pages
66-8
Notes
Journal Article
Review
Abstract
The demonstration that oral immunization with lysates of Helicobacter or with Helicobacter pylori urease can protect mice against H. felis infection opened the field of vaccine development against Helicobacter infections. More recently, the same antigen preparations were used successfully as a therapeutic vaccine able to cure the infection, and additional protective antigens were identified. Evidence from animal studies suggests that protection is medicated by mucosal antibodies, in association with a T helper type 2 cell cellular immune response. Vaccine adjuvants, delivery systems, and therapeutic vaccination are likely to be the areas of major progress in the future.
Keywords
Animals Antibodies, Bacterial/biosynthesis *Bacterial Vaccines/immunology Helicobacter Infections/*prevention & control Helicobacter pylori/*immunology Humans Urease/immunology
Pubmed
Web of science
Create date
25/01/2008 17:02
Last modification date
20/08/2019 15:49
Usage data