Treatment of pyoderma gangrenosum with topical factor XIII.

Details

Serval ID
serval:BIB_8ADA453251EB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Treatment of pyoderma gangrenosum with topical factor XIII.
Journal
European journal of dermatology
Author(s)
Hoetzenecker W., Guenova E., Mitev V., Schanz S., Ulmer A., Fierlbeck G.
ISSN
1952-4013 (Electronic)
ISSN-L
1167-1122
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
23
Number
5
Pages
653-657
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Pyoderma gangrenosum (PG) is a severe ulcerative skin disease. Despite systemic immunosuppressive therapy, PG ulcers often progress and can develop into life-threatening conditions. In this case series, we treated 6 patients suffering from recalcitrant PG with topical coagulation factor XIII, which has been shown to exert beneficial effects on tissue regeneration and wound healing. All 6 patients showed a positive response to treatment with a marked reduction in wound size that was maintained during a 3-month follow-up period. The treatment was well tolerated with no remarkable adverse effects or complications. Topical factor XIII has potential in combination with standard immunosuppressive therapy for the treatment of PG.
Keywords
Administration, Cutaneous, Anti-Inflammatory Agents/therapeutic use, Coagulants/administration & dosage, Drug Therapy, Combination, Factor XIII/administration & dosage, Female, Humans, Male, Middle Aged, Prednisolone/therapeutic use, Pyoderma Gangrenosum/drug therapy, factor FXIII, pyoderma gangrenosum, therapy
Pubmed
Web of science
Create date
27/08/2020 15:00
Last modification date
02/09/2020 6:26
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