Factors associated with elevated pulmonary arterial pressure levels on the echocardiographic assessment in patients with prior pulmonary embolism.
Details
Serval ID
serval:BIB_8ACB85640E15
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Factors associated with elevated pulmonary arterial pressure levels on the echocardiographic assessment in patients with prior pulmonary embolism.
Journal
Thrombosis Research
Working group(s)
RIETE investigators
Contributor(s)
Arcelus JI., Arcos MP., Ballaz A., Barba R., Barragán JM., Barrón M., Barrón-Andrés B., Bascuñana J., Blanco-Molina A., Boix L., Bosco J., Bueso T., Campano FJ., Cañas I., Casado I., Conget F., Contra A., Chaves E., de Miguel J., del Campo R., del Toro J., Falgá C., Fernández-Capitán C., Font C., Gabriel F., Gallego P., García-Bragado F., Gómez V., González J., Gracia V., Guil M., Guijarro R., Gutiérrez J., Hernández L., Hernández-Huerta D., Jara L., Jaras MJ., Jiménez D., Jiménez-Gil M., Lecumberri R., Lobo JL., López-Jiménez L., Lorenzo A., Macià M., Madridano O., Marchena PJ., Martín M., Martín-Villasclaras JJ., Monreal M., Morales M., Nauffal MD., Nieto JA., Núñez MJ., Ogea JL., Otero R., Pedrajas JM., Riera-Mestre A., Rodríguez-Dávila MA., Roldán V., Román P., Rodríguez EM., Rosa V., Ruíz J., Ruiz-Gamietea A., Ruiz-Giménez N., Sahuquillo JC., Sánchez R., Sánchez Muñoz-Torrero JF. , Soler S., Soto MJ., Tiberio G., Todolí JA., Tolosa C., Trujillo J., Uresandi F., Valdés M., Valero B., Valle R., Vidal G., Villalobos A., Villalta J., Zamora L., Zorrilla V., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Mahe I., Quere I., Papadakis M., Braester A., Brenner B., Zeltser D., Barillari G., Ciammaichella M., Di Micco P., Dalla Valle F., Duce R., Maida R., Pasca S., Piovella C., Poggio R., Prandoni P., Quintavalla R., Rota L., Schenone A., Tiraferri E., Tonello D., Venturelli U., Visonà A., Zalunardo B., Bosevski M., Alatri A., Aujeski D., Bounameaux H., Mazzolai L., Malý R., Tomko T., Salgado E., Schellong S., Caprini J.
ISSN
1879-2472 (Electronic)
ISSN-L
0049-3848
Publication state
Published
Issued date
2013
Volume
131
Number
5
Pages
e191-e195
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. Alatri fait partie de RIETE investigators
Abstract
BACKGROUND: Factors associated with the detection of raised systolic pulmonary artery pressure (sPAP) levels in patients with a prior episode of pulmonary embolism (PE) are not well known.
METHODS: We used the RIETE Registry database to identify factors associated with the finding of sPAP levels ≥50 mm Hg on trans-thoracic echocardiography, in 557 patients with a prior episode of acute, symptomatic PE.
RESULTS: Sixty-two patients (11.1%; 95% CI: 8.72-14.1) had sPAP levels ≥50 mm Hg. These patients were more likely women, older, and more likely had chronic lung disease, heart failure, renal insufficiency or leg varicosities than those with PAP levels <50mm Hg. During the index PE event, they more likely had recent immobility, and more likely presented with hypoxemia, increased sPAP levels, atrial fibrillation, or right bundle branch block. On multivariate analysis, women aged ≥70 years (hazard ratio [HR]: 2.0; 95% CI: 1.0-3.7), chronic heart or chronic lung disease (HR: 2.4; 95% CI: 1.3-4.4), atrial fibrillation at PE presentation (HR: 2.8; 95% CI: 1.3-6.1) or varicose veins (HR: 1.8; 95% CI: 1.0-3.3) were all associated with an increased risk to have raised sPAP levels. Chronic heart disease, varicose veins, and atrial fibrillation were independent predictors in women, while chronic heart disease, atrial fibrillation, a right bundle branch block or an S1Q3T3 pattern on the electrocardiogram were independent predictors in men.
CONCLUSIONS: Women aged ≥70 years more likely had raised sPAP levels than men after a PE episode. Additional variables influencing this risk seem to differ according to gender.
METHODS: We used the RIETE Registry database to identify factors associated with the finding of sPAP levels ≥50 mm Hg on trans-thoracic echocardiography, in 557 patients with a prior episode of acute, symptomatic PE.
RESULTS: Sixty-two patients (11.1%; 95% CI: 8.72-14.1) had sPAP levels ≥50 mm Hg. These patients were more likely women, older, and more likely had chronic lung disease, heart failure, renal insufficiency or leg varicosities than those with PAP levels <50mm Hg. During the index PE event, they more likely had recent immobility, and more likely presented with hypoxemia, increased sPAP levels, atrial fibrillation, or right bundle branch block. On multivariate analysis, women aged ≥70 years (hazard ratio [HR]: 2.0; 95% CI: 1.0-3.7), chronic heart or chronic lung disease (HR: 2.4; 95% CI: 1.3-4.4), atrial fibrillation at PE presentation (HR: 2.8; 95% CI: 1.3-6.1) or varicose veins (HR: 1.8; 95% CI: 1.0-3.3) were all associated with an increased risk to have raised sPAP levels. Chronic heart disease, varicose veins, and atrial fibrillation were independent predictors in women, while chronic heart disease, atrial fibrillation, a right bundle branch block or an S1Q3T3 pattern on the electrocardiogram were independent predictors in men.
CONCLUSIONS: Women aged ≥70 years more likely had raised sPAP levels than men after a PE episode. Additional variables influencing this risk seem to differ according to gender.
Pubmed
Web of science
Create date
11/02/2014 16:11
Last modification date
03/06/2020 5:26
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