NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.

Details

Serval ID
serval:BIB_8A4FB9CDB826
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.
Journal
Nature communications
Author(s)
Compans B., Camus C., Kallergi E., Sposini S., Martineau M., Butler C., Kechkar A., Klaassen R.V., Retailleau N., Sejnowski T.J., Smit A.B., Sibarita J.B., Bartol T.M., Perrais D., Nikoletopoulou V., Choquet D., Hosy E.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
14/05/2021
Peer-reviewed
Oui
Volume
12
Number
1
Pages
2849
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD encompasses various induction pathways, including activation of NMDA, mGlu or P2X receptors. However, the associated specific molecular mechanisms and effects on synaptic physiology are still unclear. We here compare how NMDAR- or P2XR-dependent LTD affect synaptic nanoscale organization and function in rodents. While both LTDs are associated with a loss and reorganization of synaptic AMPARs, only NMDAR-dependent LTD induction triggers a profound reorganization of PSD-95. This modification, which requires the autophagy machinery to remove the T19-phosphorylated form of PSD-95 from synapses, leads to an increase in AMPAR surface mobility. We demonstrate that these post-synaptic changes that occur specifically during NMDAR-dependent LTD result in an increased short-term plasticity improving neuronal responsiveness of depressed synapses. Our results establish that P2XR- and NMDAR-mediated LTD are associated to functionally distinct forms of LTD.
Pubmed
Open Access
Yes
Create date
25/05/2021 13:54
Last modification date
02/11/2021 6:39
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