Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease.

Details

Serval ID
serval:BIB_8A2E6E8F0FBB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease.
Journal
Journal of Infectious Diseases
Author(s)
Erard Veronique, Wald Anna, Corey Lawrence, Leisenring Wendy M., Boeckh Michael
ISSN
0022-1899
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
196
Number
2
Pages
266-270
Language
english
Abstract
The effect that long-term use of suppressive acyclovir (ACV) has on both overall herpes simplex virus (HSV) disease and ACV-resistant HSV disease was examined in 3 consecutive cohorts of hematopoietic stem-cell transplant (HCT) recipients (n=2049); cohort 1 received ACV for 30 days after HCT, cohort 2 received it for 1 year after HCT, and cohort 3 received it for an extended period (i.e., >1 year) if the patient's immunosuppression continued after 1 year. The 2-year probability of HSV disease was 31.6% (95% confidence interval [CI], 28.0%-35%) in cohort 1, 3.9% (95% CI, 2.7%-5.2%) in cohort 2, and 0% in cohort 3 (P<.001). ACV-resistant HSV disease developed in 10 patients in cohort 1 (2-year probability, 1.3% [95% CI, 0.8%-2.7%]), in 2 patients in cohort 2 (2-year probability, 0.2% [95% CI, 0%-0.8%]; P=.006), and in 0 patients in cohort 3 (cohort 2 vs. cohort 3, P=.3). Long-term use of suppressive prophylactic ACV appears to prevent the emergence of drug-resistant HSV disease in HCT.
Keywords
Acyclovir/administration & dosage, Adolescent, Adult, Aged, Antiviral Agents/administration & dosage, Child, Child, Preschool, Drug Administration Schedule, Drug Resistance, Viral, Hematopoietic Stem Cell Transplantation, Herpes Simplex/prevention & control, Humans, Infant, Longitudinal Studies, Middle Aged, Retrospective Studies, Simplexvirus/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2010 16:43
Last modification date
20/08/2019 15:49
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