Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats

Details

Serval ID
serval:BIB_8A1D2F5B19F5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats
Journal
Eur Respir J
Author(s)
Tillie-Leblond I., Gosset P., Le Berre R., Janin A., Prangere T., Tonnel A. B., Guery B. P.
ISSN
0903-1936 (Print)
ISSN-L
0903-1936
Publication state
Published
Issued date
07/2007
Volume
30
Number
1
Pages
31-9
Language
english
Notes
Tillie-Leblond, I
Gosset, P
Le Berre, R
Janin, A
Prangere, T
Tonnel, A B
Guery, B P H
eng
England
Eur Respir J. 2007 Jul;30(1):31-9. doi: 10.1183/09031936.00011606. Epub 2007 Mar 28.
Abstract
Chronic allergic asthma is associated with marked inflammatory reaction, microvascular leakage and epithelium injury. As previously shown in a rat model of chronic asthma, these alterations increase lung permeability and distal airway fluid clearance. Keratinocyte growth factor (KGF) has been shown to induce epithelial cell proliferation and to protect from acute lung injuries. Therefore, the current authors evaluated the potential role of KGF treatment on lung permeability and airway inflammation in rats with chronic asthma. KGF (1 mg x kg(-1)) was administered intravenously before the last ovalbumin (OVA) challenge in sensitised rats. Permeability was assessed by the leak of radiolabelled albumin from the alveolar and systemic compartments. Histopathological analysis was also performed. Treatment with KGF decreased the leak of both markers and decreased the level of extravascular lung water in sensitised rats challenged with OVA. KGF treatment also reduced the inflammatory cell number in bronchoalveolar lavage fluid but not in bronchial mucosa. KGF markedly limited the allergen-induced alterations in epithelium integrity and the expression of the intercellular junction proteins beta-catenin and zonula occludens protein-1. In conclusion, keratinocyte growth factor administration markedly limits lung permeability and airway inflammation, an effect associated with a decrease in epithelium alterations during chronic allergic asthma. These data open new prospects in the therapeutic strategy of asthma.
Keywords
Animals, Asthma/metabolism, Bronchi/*metabolism, Epithelial Cells/metabolism, Epithelium/*metabolism, Fibroblast Growth Factor 7/*metabolism, Hypersensitivity, Inflammation, Lung/metabolism/*pathology, Male, Mucous Membrane/metabolism, Ovalbumin/metabolism, Permeability, Rats, beta Catenin/metabolism
Pubmed
Create date
29/04/2021 9:59
Last modification date
30/04/2021 5:38
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