Sirolimus-associated eyelid edema in kidney transplant recipients

Details

Serval ID
serval:BIB_89F3E47E2581
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sirolimus-associated eyelid edema in kidney transplant recipients
Journal
Transplantation
Author(s)
Mohaupt  M. G., Vogt  B., Frey  F. J.
ISSN
0041-1337 (Print)
Publication state
Published
Issued date
07/2001
Volume
72
Number
1
Pages
162-4
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jul 15
Abstract
BACKGROUND: The immunosuppressant sirolimus is effective in preventing acute rejection episodes. So far, unusual edema formation has not been reported as a side effect. METHODS: Two groups of patients with renal transplants, consisting of 11 patients each, were followed for up to 29 months. The immunosuppressive regimen was either sirolimus and prednisone with or without cyclosporine or azathioprine/mycophenolate and prednisone with cyclosporine. Routine follow-up included a thorough clinical investigation. Edema formation was documented photographically. RESULTS: In 5 of the 11 patients treated with sirolimus uni- or bilateral, non-itching, eyelid edema was observed. After discontinuation of sirolimus, lid edema disappeared. The duration until recovery varied from weeks to months. No cause of edema formation other than the treatment with sirolimus was detected. CONCLUSIONS: Severe eyelid edema formation seems to be associated with sirolimus treatment. The underlying mechanism is unknown.
Keywords
Adolescent Adult Aged Drug Therapy, Combination Edema/*chemically induced Eyelid Diseases/*chemically induced Follow-Up Studies Humans Immunosuppressive Agents/*adverse effects *Kidney Transplantation Middle Aged Retrospective Studies Sirolimus/*adverse effects
Pubmed
Web of science
Create date
25/01/2008 13:03
Last modification date
20/08/2019 14:48
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