Cortical and subcortical control of tongue movement in humans: a functional neuroimaging study using fMRI.

Details

Serval ID
serval:BIB_89D5914500B9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cortical and subcortical control of tongue movement in humans: a functional neuroimaging study using fMRI.
Journal
Journal of Applied Physiology
Author(s)
Corfield D.R., Murphy K., Josephs O., Fink G.R., Frackowiak R.S., Guz A., Adams L., Turner R.
ISSN
8750-7587 (Print)
ISSN-L
0161-7567
Publication state
Published
Issued date
1999
Volume
86
Number
5
Pages
1468-1477
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
We have used voluntary tongue contraction to test whether we can image activation of the hypoglossal nuclei within the human brain stem by using functional magnetic resonance imaging (fMRI). Functional images of the whole brain were acquired in eight subjects by using T2-weighted echo planar imaging (blood oxygen level development) every 6.2 s. Sequences of images were acquired during 12 periods of 31-s "isometric" rhythmic tongue contraction alternated with 12 periods of 31-s tongue relaxation. Noise arising from cardiac- and respiratory-related movement was removed either by filtration (high pass; cutoff 120 s) or by inclusion in the statistical analysis as confounding effects of no interest. For the group, tongue contraction was associated with significant signal increases (P < 0.05 corrected for multiple comparisons) in the sensorimotor cortex, supplementary motor area, operculum, insula, thalamus, and cerebellum. For the group and for six of eight individuals, significant signal increases were also seen within the medulla (P < 0.001, predefined region of interest with no correction for multiple comparisons); this signal is most likely to reflect neuronal activation associated with the hypoglossal motor nuclei. The data demonstrate that fMRI can be used to detect, simultaneously, the cerebral and brain stem control of tongue movement.
Keywords
Adult, Brain/physiology, Brain Mapping, Female, Heart Rate/physiology, Hemodynamics/physiology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex/physiology, Movement/physiology, Muscle Contraction/physiology, Respiratory Mechanics/physiology, Tongue/innervation, Tongue/physiology
Pubmed
Web of science
Create date
12/09/2011 20:44
Last modification date
20/08/2019 14:48
Usage data