Radio-chimiotherapie neo-adjuvante du carcinome epidermoide de l'oesophage. [Neo-adjuvant radio-chemotherapy of epidermoid carcinoma of the esophagus]

Details

Serval ID
serval:BIB_898CA39B74ED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Radio-chimiotherapie neo-adjuvante du carcinome epidermoide de l'oesophage. [Neo-adjuvant radio-chemotherapy of epidermoid carcinoma of the esophagus]
Journal
Helvetica Chirurgica Acta
Author(s)
Hellbardt  A., Aapro  M., Sappino  A. P., Mirimanoff  R. O., Megevand  R.
ISSN
0018-0181 (Print)
Publication state
Published
Issued date
12/1989
Volume
56
Number
4
Pages
435-41
Notes
English Abstract
Journal Article --- Old month value: Dec
Abstract
In spite of progress in surgery and radiation therapy, esophageal squamous cell carcinoma's outlook remains grim with a cure rate of approximately 10%. The high failure rate is not only due to loco-regional failure but also to distant metastasis. The association of preoperative chemotherapy with radiation has gained interest with hope to improve control of this disease. The present pilot study is an alternating treatment of chemotherapy and radiotherapy for poor risk carcinomas of the esophagus, not primarily amenable to surgery. The chemotherapy is composed of Cis-Platinum 60 mg/m2 Day 1 (D), Mitomycin 8 mg/m2 D1 and Vindesin 3 mg/m2 D1 and D8, alternating with radiotherapy twice 20 Gy in fraction of 2 Gy per day. After reevaluation patients are if possible submitted to surgery and if not, to a third course of treatment to a total of 3 courses and 60 Gy. Seventeen patients were entered in our study with 15 evaluable. The radiochemotherapeutic association was overall well tolerated with no toxic deaths due to treatment. Seven patients had symptomatic improvement after the first treatment cycle. The presurgical evaluation showed 8 CR and 3 PR. Eight patients have been operated with 3 pathological CR and 3 PR. Five patients completed the 3 courses of chemo- and radiotherapy (without surgery) with no improvement compared to the workup before the third course. The survival is as follows: among the 8 operated: 4 are alive without evidence of disease and 4 are dead with 2 postoperative deaths and 1 local recurrence.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Aged Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma, Squamous Cell/*drug therapy/radiotherapy Combined Modality Therapy Esophageal Neoplasms/*drug therapy/radiotherapy Female Follow-Up Studies Humans Male Middle Aged Radiotherapy Dosage
Pubmed
Web of science
Create date
24/01/2008 17:12
Last modification date
20/08/2019 14:48
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