Glycosylation pathways as drug targets for cancer: glycosidase inhibitors.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_897949D260C8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Glycosylation pathways as drug targets for cancer: glycosidase inhibitors.
Journal
Mini Reviews in Medicinal Chemistry
Author(s)
Gerber-Lemaire S., Juillerat-Jeanneret L.
ISSN
1389-5575
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
6
Number
9
Pages
1043-1052
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The combined and ordered sequential action of glycosidases and glycosyltransferases in mammalian cell compartments leads to the addition of defined glycans to proteins and lipids. Altered glycosylation patterns, neoexpression, underexpression or overexpression of glycans are a hallmark of cancer. These changes are either found in the core or the terminal structures of the carbohydrates of glycoproteins. Affected proteins can be either cellular, cell-surface or secreted proteins, and glycosylation modifications frequently result in a modified expression, metabolism, functions, properties, stability and/or cellular localization of glycoproteins in cancer cells, resulting in part in their uncontrolled growth and aggressive behavior. Therefore glycosylation pathways, and the glycosidases and glycosyltransferases of these pathways, represent potential innovative modalities for drug development in cancer therapies which are just beginning to be explored. This review proposes to summarize the published information for glycosidases and their inhibitors in cancer.
Keywords
Antineoplastic Agents, Glycoside Hydrolases, Glycosylation, Humans, Molecular Structure, Neoplasms
Pubmed
Web of science
Create date
29/01/2008 18:34
Last modification date
11/06/2020 5:21
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