Adverse reactions to biologic agents and their medical management.

Details

Serval ID
serval:BIB_897931CEA415
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adverse reactions to biologic agents and their medical management.
Journal
Nature Reviews. Rheumatology
Author(s)
Boyman O., Comte D., Spertini F.
ISSN
1759-4804 (Electronic)
ISSN-L
1759-4790
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
10
Number
10
Pages
612-627
Language
english
Notes
Publication types: REVIEW Publication Status: ppublish
Abstract
Biologic agents have substantially advanced the treatment of immunological disorders, including chronic inflammatory and autoimmune diseases. However, these drugs are often associated with adverse events (AEs), including allergic, immunological and other unwanted reactions. AEs can affect almost any organ or system in the body and can occur immediately, within minutes to hours, or with a delay of several days or more after initiation of biologic therapy. Although some AEs are a direct consequence of the functional inhibition of biologic-agent-targeted antigens, the pathogenesis of other AEs results from a drug-induced imbalance of the immune system, intermediary factors and cofactors, a complexity that complicates their prediction. Herein, we review the AEs associated with biologic therapy most relevant to rheumatic and immunological diseases, and discuss their underlying pathogenesis. We also include our recommendations for the medical management of such AEs. Increased understanding and improved risk management of AEs induced by biologic agents will enable better use of these versatile immune-response modifiers.
Pubmed
Web of science
Create date
06/11/2014 20:09
Last modification date
20/08/2019 15:48
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