The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_89789D021BFC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis.
Journal
Cancers
Author(s)
Albano D., Rizzo A., Racca M., Muoio B., Bertagna F., Treglia G.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
05/05/2024
Peer-reviewed
Oui
Volume
16
Number
9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-deoxy-2-[ <sup>18</sup> F]-fluoro-D-glucose positron emission tomography/computed tomography (2-[ <sup>18</sup> F]FDG PET/CT) has been shown to be a non-invasive and promising tool, but apparently, unclear data seem to be present in the literature. This systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[ <sup>18</sup> F]FDG PET/CT and its parameters in predicting RT. Between 2006 and 2024, 15 studies were published on this topic, including 1593 CLL patients. Among semiquantitative variables, SUV <sub>max</sub> was the most investigated, and the best threshold derived for detecting RT was five. With this cut-off value, a pooled sensitivity of 86.8% (95% CI: 78.5-93.3), a pooled specificity of 48.1% (95% CI: 27-69.9), a pooled negative predictive value of 90.5% (95% CI: 88.4-92.4), a pooled negative likelihood ratio of 0.35 (95% CI: 0.17-0.70), a pooled positive likelihood ratio of 1.8 (95% CI: 1.3-2.4), and a pooled diagnostic odds ratio of 6.7 (3.5-12.5) were obtained. With a higher cut-off (SUV <sub>max</sub> = 10), the specificity increased while the sensitivity reduced. The other metabolic features, like metabolic tumor volume, total lesion glycolysis, and radiomic features, were only marginally investigated with controversial evidence.
Keywords
Cll, Fdg, Pet/ct, Richter transformation, Suv, meta-analysis, systematic review, CLL, FDG, PET/CT, SUV
Pubmed
Web of science
Open Access
Yes
Create date
16/05/2024 15:31
Last modification date
25/05/2024 7:13
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