Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Details

Serval ID
serval:BIB_89683D37876F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Gao V., Suzuki A., Magistretti P.J., Lengacher S., Pollonini G., Steinman M.Q., Alberini C.M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
26/07/2016
Peer-reviewed
Oui
Volume
113
Number
30
Pages
8526-8531
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2-adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long-term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.

Keywords
Adrenergic beta-Antagonists/administration & dosage, Adrenergic beta-Antagonists/pharmacology, Analysis of Variance, Animals, Astrocytes/metabolism, Hippocampus/drug effects, Hippocampus/metabolism, Hippocampus/physiology, Lactic Acid/metabolism, Lactic Acid/pharmacology, Learning/physiology, Male, Memory, Long-Term/drug effects, Memory, Long-Term/physiology, Propanolamines/administration & dosage, Propanolamines/pharmacology, Propranolol/administration & dosage, Propranolol/pharmacology, RNA Interference, Rats, Long-Evans, Receptors, Adrenergic, beta-2/genetics, Receptors, Adrenergic, beta-2/metabolism, Time Factors, astrocyte, hippocampus, lactate, memory, β-adrenergic receptor
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2016 17:54
Last modification date
20/08/2019 15:48
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