Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.

Details

Serval ID
serval:BIB_892031542373
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.
Journal
International Journal of Leprosy and other Mycobacterial Diseases
Author(s)
Drowart A., Chanteau S., Huygen K., De Cock M., Cartel J.L., De Bruyn J., Launois P., Yernault J.C., Van Vooren J.P.
ISSN
0148-916X (Print)
ISSN-L
0148-916X
Publication state
Published
Issued date
1993
Volume
61
Number
1
Pages
29-34
Language
english
Abstract
IgG antibodies against antigens 85A and 85B from Mycobacterium bovis BCG, IgM antibodies against phenolic glycolipid-I (PGL-I) and circulating PGL-I antigen were measured in the serum of 11 patients with lepromatous leprosy receiving multidrug therapy (MDT). Before treatment, 6 patients were reactive to antigen 85A, 10 patients to antigen 85B, and 11 patients to PGL-I; circulating PGL-I was detected in the sera of all of them. After 2 years of MDT PGL-I antigen could no longer be detected in all of the patients, except for two who were not compliant with treatment. IgG antibodies directed against the 85A and 85B antigens and IgM antibodies against the PGL-I antigen also decreased significantly during treatment but more slowly. The determination of circulating PGL-I antigen remains the most appropriate tool for monitoring lepromatous leprosy under MDT.
Keywords
Antibodies, Bacterial/blood, Antigens, Bacterial/immunology, Clofazimine/therapeutic use, Dapsone/therapeutic use, Drug Therapy, Combination, Glycolipids/blood, Glycolipids/immunology, Humans, Immunoglobulin G/blood, Immunoglobulin M/blood, Isoelectric Focusing, Leprostatic Agents/therapeutic use, Leprosy, Lepromatous/drug therapy, Leprosy, Lepromatous/immunology, Mycobacterium bovis/immunology, Mycobacterium leprae/immunology, Patient Compliance, Prothionamide/therapeutic use, Rifampin/therapeutic use
Pubmed
Web of science
Create date
28/01/2008 11:06
Last modification date
20/08/2019 14:48
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