TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Details
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_8915C0704772
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Journal
Nature Immunology
ISSN
1529-2916 (Electronic)
ISSN-L
1529-2908
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
16
Number
9
Pages
970-979
Language
english
Abstract
Interleukin 17-producing helper T cells (TH17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.
Pubmed
Create date
15/09/2015 17:23
Last modification date
21/11/2022 9:19