TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

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Serval ID
serval:BIB_8915C0704772
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Journal
Nature Immunology
Author(s)
Meller S., Di Domizio J., Voo K.S., Friedrich H.C., Chamilos G., Ganguly D., Conrad C., Gregorio J., Le Roy D., Roger T., Ladbury J.E., Homey B., Watowich S., Modlin R.L., Kontoyiannis D.P., Liu Y.J., Arold S.T., Gilliet M.
ISSN
1529-2916 (Electronic)
ISSN-L
1529-2908
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
16
Number
9
Pages
970-979
Language
english
Abstract
Interleukin 17-producing helper T cells (TH17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.
Pubmed
Create date
15/09/2015 17:23
Last modification date
20/08/2019 15:48
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