Génériques des médicaments antiépileptiques [Generics of antiepileptic drugs]

Details

Serval ID
serval:BIB_8909A748E94A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Génériques des médicaments antiépileptiques [Generics of antiepileptic drugs]
Journal
Revue Médicale Suisse
Author(s)
Maeder-Ingvar M., Foletti G.B.
ISSN
1660-9379[print], 1660-9379[linking]
Publication state
Published
Issued date
2010
Volume
6
Number
247
Pages
907-909
Language
french
Notes
Publication types: English Abstract ; Journal Article
Abstract
Generic substitution of antiepileptic drugs (EAD) have limited use because epilepsy is a chronic disease, seizure recurrence has an important impact of the quality of life and the potential risk of accidents. EADs have a narrow therapeutic window, non negligible side effects and complex interactions. Bioavailability of generic EADs, tested in healthy men during a limited period of time must be within the 90% IC, in which means that serum levels can range from 80% to 125% of the original drug. A slight drop in serum level could increase the risk of seizure recurrence, as indicated by several publications. Although no formal studies regarding cost effectiveness and the rate of seizure recurrence is available yet, the prevailing consensus recommends not to replace an original antiepileptic drug by a generic, due to the harmful risk of seizure recurrence.
Keywords
Anticonvulsants/economics, Anticonvulsants/pharmacokinetics, Drug Costs, Drug Interactions, Drug Prescriptions, Drugs, Generic/adverse effects, Drugs, Generic/economics, Epilepsy/drug therapy, Humans, Practice Guidelines as Topic, Quality of Life, Recurrence/prevention & control, Risk Factors, Time Factors, Treatment Outcome
Pubmed
Create date
18/08/2010 17:18
Last modification date
20/08/2019 14:48
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