What animals can teach clinicians about the hippocampus

Details

Serval ID
serval:BIB_88F7EACD995C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
What animals can teach clinicians about the hippocampus
Journal
The Hippocampus in Clinical Neuroscience
Author(s)
Lavenex P., Banta Lavenex P., Favre G.
ISSN
978-3-318-02567-5 (Print)
eISBN: 978-3-318-02568-2 (Online)
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
34
Pages
36-50
Language
english
Notes
Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Abnormalities in hippocampal structure and function have been reported in a number of human neuropathological and neurodevelopmental disorders, including Alzheimer's disease, autism spectrum disorders, Down syndrome, epilepsy, and schizophrenia. Given the complexity of these disorders, animal studies are invaluable and remain to date irreplaceable, providing fundamental knowledge regarding the basic mechanisms underlying normal and pathological human brain structure and function. However, there is a prominent ill-conceived view in current research that scientists should be restricted to using animal models of human diseases that can lead to results applicable to humans within a few years. Although there is no doubt that translational studies of this kind are important and necessary, limiting animal studies to applicable questions is counterproductive and will ultimately lead to a lack of knowledge and an inability to address human health problems. Here, we discuss findings regarding the normal postnatal development of the monkey hippocampal formation, which provide an essential framework to consider the etiologies of different neuropathological disorders affecting human hippocampal structure and function. We focus on studies of gene expression in distinct hippocampal regions that shed light on some basic mechanisms that might contribute to the etiology of schizophrenia. We argue that researchers, as well as clinicians, should not consider the use of animals in research only as 'animal models' of human diseases, as they will continue to need and benefit from a better understanding of the normal structure and functions of the hippocampus in 'model animals'.
Pubmed
Web of science
Create date
25/09/2014 18:19
Last modification date
20/08/2019 15:48
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