Soft tissue sarcomas of the trunk wall (STS-TW): a study of 343 patients from the French Sarcoma Group (FSG) database.

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Serval ID
serval:BIB_88E97C7F8E56
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Soft tissue sarcomas of the trunk wall (STS-TW): a study of 343 patients from the French Sarcoma Group (FSG) database.
Journal
Annals of Oncology
Author(s)
Salas S., Bui B., Stoeckle E., Terrier P., Ranchere-Vince D., Collin F., Leroux A., Guillou L., Michels J.J., Trassard M., Valo I., Robin Y.M., Marques B., Brouste V., Coindre J.M.
ISSN
1569-8041[electronic], 0923-7534[linking]
Publication state
Published
Issued date
2009
Volume
20
Number
6
Pages
1127-1135
Language
english
Abstract
BACKGROUND: Soft tissue sarcomas of the trunk wall (STS-TW) are usually studied together with soft tissue sarcomas of other locations. We report a study on STS-TW forming part of the French Sarcoma Group database. PATIENTS AND METHODS: Three hundred and forty-three adults were included. We carried out univariate and multivariate analysis for overall survival (OS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS). RESULTS: Tumor locations were as follows: thoracic wall, 82.5%; abdominal wall, 12.3% and pelvic wall, 5.2%. Median tumor size was 6.0 cm. The most frequent tumor types were unclassified sarcoma (27.7%) and myogenic sarcoma (19.2%). A total of 44.6% of cases were grade 3. In all, 21.9% of patients had a previous medical history of radiotherapy (PHR). Median follow-up was 7.6 years. The 5-year OS, MFS and LRFS rates were 60.4%, 68.9% and 58.4%, respectively. Multivariate analysis retained PHR and grade for predicting LRFS and PHR, size and grade as prognostic factors of MFS. Factors influencing OS were age, size, PHR, depth, grade and surgical margins. The predictive factors of incomplete response were PHR, size and T3. CONCLUSIONS: Our results suggest similar classical prognostic factors as compared with sarcomas of other locations. However, a separate analysis of STS-TW revealed a significant poor prognosis subgroup of patients with PHR.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Databases as Topic, Female, Humans, Male, Middle Aged, Sarcoma/mortality, Sarcoma/pathology, Survival Analysis, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
20/05/2009 19:35
Last modification date
25/09/2019 7:09
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