Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.

Details

Serval ID
serval:BIB_88E4438147B5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.
Journal
Clinical pharmacokinetics
Author(s)
Csajka C., Buclin T., Brunner H.R., Biollaz J.
ISSN
0312-5963
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
32
Number
1
Pages
1-29
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
The pharmacokinetic and pharmacodynamic properties of nonpeptide angiotensin antagonists in humans are reviewed in this paper. Representatives of this new therapeutic class share common features: lipophilia, intermediate bioavailability, high affinity for plasma proteins and liver metabolism; some have active metabolites. Angiotensin II antagonists block the blood pressure response to exogenous angiotensin II in healthy volunteers, decrease baseline blood pressure in both normal and hypertensive patients, produce a marked rise in plasma renin activity and endogenous angiotensin II and increase renal blood flow without altering glomerular filtration rate. These effects are dose-dependent, but their time course varies between the drugs owing to pharmacokinetic and pharmacodynamic differences. Additionally, the extent of blood pressure reduction is dependent on physiological factors such as sodium and water balance. The characterisation of their pharmacokinetic-pharmacodynamic relationships deserves further refinement for designing optimal therapeutic regimens and proposing dosage adaptations in specific conditions.
Keywords
Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Anti-Arrhythmia Agents, Antihypertensive Agents, Benzimidazoles, Biphenyl Compounds, Clinical Trials as Topic, Humans, Imidazoles, Losartan, Receptors, Angiotensin, Renin, Tetrazoles, Valine
Pubmed
Web of science
Create date
25/01/2008 10:48
Last modification date
20/08/2019 14:47
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