The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.

Details

Serval ID
serval:BIB_88E0858A93EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
Journal
Immunobiology
Author(s)
Korver W., Roose J., Wilson A., Clevers H.
ISSN
0171-2985 (Print)
ISSN-L
0171-2985
Publication state
Published
Issued date
1997
Volume
198
Number
1-3
Pages
157-161
Language
english
Abstract
We recently identified the winged-helix transcription factor Trident and described its expression pattern in synchronized fibroblasts. We have now studied Trident expression in cell lines, differentiating thymocytes and in lymphocytes derived from peripheral blood. During T cell differentiation, expression peaked in the actively dividing immature single positive cells. In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes.
Keywords
Cell Cycle, Cell Differentiation, Cell Line, Forkhead Transcription Factors, Humans, T-Lymphocytes/cytology, T-Lymphocytes/metabolism, Thymus Gland/cytology, Transcription Factors/biosynthesis, Transcription Factors/genetics, Tumor Cells, Cultured
Pubmed
Web of science
Create date
11/04/2013 10:54
Last modification date
20/08/2019 14:47
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