Relationship between stress, inflammation and metabolism.

Details

Serval ID
serval:BIB_887A0D5D0204
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Relationship between stress, inflammation and metabolism.
Journal
Current opinion in clinical nutrition and metabolic care
Author(s)
Seematter G., Binnert C., Martin J.L., Tappy L.
ISSN
1363-1950
Publication state
Published
Issued date
03/2004
Peer-reviewed
Oui
Volume
7
Number
2
Pages
169-73
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: Various threatening stimuli, such as pain, low blood pressure, or infection, elicit a set of neuroendocrine responses that include an increased secretion of catecholamines and glucocorticoid from the adrenal gland and activation of the sympathetic nervous system. These hormonal secretions allow a "fight or flight" response by mobilizing endogenous substrate. They also exert anti-insulin actions, and may in the long term induce a state of insulin resistance. In addition, stress stimulates inflammatory mediators in mononuclear cells. Given the possible role of low-grade inflammation in chronic metabolic disorders, this suggests that stress may be a factor in the development of insulin resistance and the metabolic syndrome. RECENT FINDINGS: Studies reviewed in this article cover: (1) the metabolic and haemodynamic effects of stress in healthy and insulin-resistant individuals; (2) the relationship between stress and inflammation and the role of the autonomic nervous system; and (3) some factors known to modulate the neuroendocrine responses to stress. Future perspectives, together with some hints regarding the role of neurotrophins such as brain-derived neurotrophic factor, are delineated. SUMMARY: Recent work performed in the field has indicated that stress may be a significant factor in the pathogenesis of metabolic disorders. Nutritional intervention or pharmacological agents targeted at modulating stress should be investigated.
Keywords
Cytokines, Energy Metabolism, Humans, Inflammation, Insulin Resistance, Metabolic Diseases, Oxidative Stress, Stress, Physiological
Pubmed
Web of science
Create date
20/01/2008 19:22
Last modification date
20/08/2019 15:47
Usage data