Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.

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Version: Final published version
Serval ID
serval:BIB_8854BDE329EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.
Journal
Plos One
Author(s)
Lyngdoh Tanica, Marques-Vidal Pedro, Paccaud Fred, Preisig Martin, Waeber Gérard, Bochud Murielle, Vollenweider Peter
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
6
Number
5
Pages
e19901
Language
english
Abstract
BACKGROUND: The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent. We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor- alpha (TNF-alpha) and C-reactive protein (CRP). METHODS AND FINDINGS: This cross-sectional population-based study conducted in Lausanne, Switzerland, included 6085 participants aged 35 to 75 years. SUA was measured using uricase-PAP method. Plasma TNF-alpha, IL-1beta and IL-6 were measured by a multiplexed particle-based flow cytometric assay and hs-CRP by an immunometric assay. The median levels of SUA, IL-6, TNF-alpha, CRP and IL-1beta were 355 micromol/L, 1.46 pg/mL, 3.04 pg/mL, 1.2 mg/L and 0.34 pg/mL in men and 262 micromol/L, 1.21 pg/mL, 2.74 pg/mL, 1.3 mg/L and 0.45 pg/mL in women, respectively. SUA correlated positively with IL-6, TNF-alpha and CRP and negatively with IL-1beta (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P<0.05). In multivariable analyses, SUA was associated positively with CRP (beta coefficient +/- SE = 0.35+/-0.02, P<0.001), TNF-alpha (0.08+/-0.02, P<0.001) and IL-6 (0.10+/-0.03, P<0.001), and negatively with IL-1beta (-0.07+/-0.03, P = 0.027). Upon further adjustment for body mass index, these associations were substantially attenuated. CONCLUSIONS: SUA was associated positively with IL-6, CRP and TNF-alpha and negatively with IL-1beta, particularly in women. These results suggest that uric acid contributes to systemic inflammation in humans and are in line with experimental data showing that uric acid triggers sterile inflammation.
Keywords
Adult, Aged, C-Reactive Protein/metabolism, Cross-Sectional Studies, Cytokines/blood, Female, Flow Cytometry, Humans, Inflammation/blood, Inflammation/epidemiology, Interleukin-1beta/blood, Interleukin-6/blood, Male, Middle Aged, Switzerland/epidemiology, Tumor Necrosis Factor-alpha/blood, Uric Acid/blood, Colaus Study
Pubmed
Web of science
Open Access
Yes
Create date
01/06/2011 13:55
Last modification date
20/08/2019 14:47
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