Maternal PTSD and corresponding neural activity mediate effects of child exposure to violence on child PTSD symptoms

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Ressource 1Download: Schechter et al., 2017 journal.pone.0181066.pdf (1928.30 [Ko])
State: Public
Version: Final published version
License: CC0 1.0
Serval ID
serval:BIB_884B20697F10
Type
Article: article from journal or magazin.
Collection
Publications
Title
Maternal PTSD and corresponding neural activity mediate effects of child exposure to violence on child PTSD symptoms
Journal
PLoS ONE
Author(s)
Schechter Daniel S
Publication state
Published
Issued date
2017
Language
english
Abstract
The aim of this study was to examine the relationship of maternal interpersonal violencerelated posttraumatic stress disorder (IPV-PTSD), associated neural activity in response to
mother-child relational stimuli, and child psychopathology indicators at child ages 12–42
months and one year later. The study tested the hypothesis that decreased maternal neural
activity in regions that subserve emotion regulation would be associated with child symptoms
associated with emotional dysregulation at both time points. Functional magnetic resonance
imaging of 42 mothers with or without violence-exposure and associated IPV-PTSD were
assessed. Their child’s life-events and symptoms/behaviors indicative of high-risk subsequent PTSD diagnosis on a maternal-report questionnaire were measured one year later.
Maternal IPV-PTSD severity was significantly associated with decreased ventromedial prefrontal cortex (vmPFC) activation in response to mother-child relational stimuli. Maternal IPVPTSD severity and decreased vmPFC activation were then significantly associated with a
child attachment disturbance at 12–42 months and symptoms/behaviors one year later, that
were correlated with emotional dysregulation and risk for child PTSD. Maternal IPV-PTSD
and child exposure to IPV were both predictive of child PTSD symptoms with maternal IPVPTSD likely mediating the effects of child IPV exposure on child PTSD symptoms. These findings suggest that maternal IPV-PTSD severity and associated decreased vmPFC activity in
response to mother-child relational stimuli are predictors of child psychopathology by age 12–
42 months and one-year later. Significant findings in this paper may well be useful in understanding how maternal top-down cortico-limbic dysregulation promotes intergenerational
transmission of IPV and related psychopathology and, thus should be targeted in treatment
Open Access
Yes
Funding(s)
Swiss National Science Foundation
Create date
19/11/2020 16:22
Last modification date
20/11/2020 6:26
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