The use of ibotenic acid lesions for light and electron microscopic study of anterograde degeneration in the visual pathway of the cat

Details

Serval ID
serval:BIB_883B5E205723
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The use of ibotenic acid lesions for light and electron microscopic study of anterograde degeneration in the visual pathway of the cat
Journal
Neuroscience Letters
Author(s)
Garey  L. J., Hornung  J. P.
ISSN
0304-3940 (Print)
Publication state
Published
Issued date
09/1980
Volume
19
Number
2
Pages
117-23
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
Ibotenic acid was injected in the lateral geniculate nucleus of cats to investigate the suitability of the technique in studies involving anterograde degeneration in the thalamo-cortical pathway when it is important not to damage fibres of passage at the lesion site. Small injections cause localized degeneration of neuronal somata in the lateral geniculate nucleus, but axons passing through the injected zone remain intact. Degeneration can be localized in visual cortex by light microscopic silver techniques and by electron microscopy. The appearance, density and distribution of degenerating cortical axon terminals is similar to what is found after thalamic electrolytic lesions.
Keywords
Animals Brain Mapping/*methods Cats Geniculate Bodies/*anatomy & histology/ultrastructure Ibotenic Acid/*pharmacology Microscopy, Electron Oxazoles/*pharmacology Visual Cortex/*anatomy & histology/ultrastructure Visual Pathways/anatomy & histology
Pubmed
Web of science
Create date
24/01/2008 14:22
Last modification date
20/08/2019 14:47
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