Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_87FE513817C9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.
Journal
International journal of bipolar disorders
Author(s)
Moulin F., Gholam M., Strippoli M.F., Castelao E., Merikangas K.R., Stapp E.K., Marquet P., Aubry J.M., Plessen K.J., Di Giacomo F., Glaus J., Pistis G., Lavigne B., Elowe J., Ranjbar S., Preisig M., Vandeleur C.L.
ISSN
2194-7511 (Print)
ISSN-L
2194-7511
Publication state
Published
Issued date
06/04/2022
Peer-reviewed
Oui
Volume
10
Number
1
Pages
11
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The factors involved in the transmission of mood disorders are only partially elucidated. Aside from genes, the family environment might play a crucial role in parent-child transmission. Our goals were to (1) assess the associations of parental bipolar disorder (BPD) and Major Depressive Disorder (MDD) with individual or shared family environmental factors, including traumatic events in offspring, parental separation, family cohesion and parental attitudes; and 2) test whether these factors were mediators of the association between exposure to parental mood disorders and the onset of these disorders in offspring.
The sample stems from an ongoing family high-risk study of mood disorders conducted in the French-speaking part of Switzerland. Given the strong impact of the age of onset of parental disorders on their transmission to children, parental disorders were dichotomized according to the onset (cut-off 21 years). Probands with early-onset (n = 30) and later-onset BPD (n = 51), early-onset (n = 21) and later-onset MDD (n = 47) and controls (n = 65), along with their spouses (n = 193) and offspring (n = 388; < 18 years on study inclusion), were assessed over a mean follow-up duration of 14 years (s.d: 4.6). The environmental measures were based on reports by offspring collected before the onset of their first mood episode.
Offspring of probands with later-onset BPD and offspring of probands with both early-onset and later-onset MDD reported traumatic events more frequently than comparison offspring, whereas exposure to parental separation was more frequent in all groups of high-risk offspring. Moreover, several familial environment scores including parenting attitudes differed between offspring of probands with BPD and comparison offspring. However, none of these factors were mediators of the parent-child transmission of BPD. Among the environmental factors, traumatic events were shown to be modest mediators of the transmission of early-onset MDD.
Our data do not support the implication of the assessed environmental factors in the parent-child transmission of BPD. In contrast to BPD, traumatic events partially mediate the parent-child transmission of early-onset MDD, which has important implications for intervention and prevention. Early therapeutic efforts in offspring exposed to these events are likely to reduce their deleterious impact on the risk of subsequent MDD.
Keywords
Biological Psychiatry, Psychiatry and Mental health, Family environment, Offspring of bipolar parents, Offspring of depressed parents, Parental separation, Trauma
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation
Create date
07/04/2022 9:46
Last modification date
21/07/2022 7:11
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