Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation

Details

Serval ID
serval:BIB_87E6C116AA34
Type
Article: article from journal or magazin.
Collection
Publications
Title
Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation
Journal
Cereb Cortex
Author(s)
Ostrowsky K., Magnin M., Ryvlin P., Isnard J., Guenot M., Mauguiere F.
ISSN
1047-3211 (Print)
ISSN-L
1047-3211
Publication state
Published
Issued date
04/2002
Volume
12
Number
4
Pages
376-85
Language
english
Notes
Ostrowsky, Karine
Magnin, Michel
Ryvlin, Philippe
Isnard, Jean
Guenot, Marc
Mauguiere, Francois
eng
Clinical Trial
Cereb Cortex. 2002 Apr;12(4):376-85.
Abstract
We studied painful and non-painful somaesthetic sensations elicited by direct electrical stimulations of the insular cortex performed in 43 patients with drug refractory temporal lobe epilepsy, using stereotactically implanted depth electrodes. Painful sensations were evoked in the upper posterior part of the insular cortex in 14 patients, mostly in the right hemisphere. Non-painful sensations were elicited in the posterior part of the insular cortex in 16 patients, in both hemispheres. Thus, painful and non-painful somaesthetic representations in the human insula overlap. Both types of responses showed a trend toward a somatotopic organization. These results agree with previous anatomical and unit recording studies in monkeys indicating a participation of the posterior part of the insular cortex in processing both noxious and innocuous somaesthetic stimuli. In humans, both a posterior and an anterior pain-related cortical area have been described within the insular cortex using functional imaging. Our results help to define the respective functional roles of these two insular areas. Finally, lateralization in the right hemisphere of sites where painful sensations were evoked is coherent with the hypothesis of a preponderant role of this hemisphere in species survival.
Keywords
Adult, Brain Mapping, Cerebral Cortex/diagnostic imaging/*physiopathology, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Epilepsy, Temporal Lobe/physiopathology, Female, Functional Laterality/physiology, Humans, Male, Pain/*physiopathology, Radiography, Sensation/*physiology, Stereotaxic Techniques
Pubmed
Create date
29/11/2018 12:37
Last modification date
20/08/2019 14:47
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