Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes

Details

Serval ID
serval:BIB_87C8F32DF771
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes
Journal
European Child and Adolescent Psychiatry
Author(s)
Eliez  S., Palacio-Espasa  F., Spira  A., Lacroix  M., Pont  C., Luthi  F., Robert-Tissot  C., Feinstein  C., Schorderet  D. F., Antonarakis  S. E., Cramer  B.
ISSN
1018-8827 (Print)
Publication state
Published
Issued date
06/2000
Volume
9
Number
2
Pages
109-14
Notes
Case Reports
Journal Article --- Old month value: Jun
Abstract
This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for individuals with this chromosomal deletion led us to examine the psychiatric and cognitive status of young children with VCFS. Our observations suggest a phenotype comprised of a borderline to mildly retarded level of intellectual functioning, a language delay, a general deficit in social initiation, difficulties with attention/concentration, and a perturbed train of thought.
Keywords
Child, Preschool Craniofacial Abnormalities/complications Female Heart Defects, Congenital/complications Humans *Language Male Mental Disorders/*etiology Phenotype *Speech Syndrome
Pubmed
Web of science
Create date
28/01/2008 12:59
Last modification date
20/08/2019 14:47
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