Thermogenic and metabolic effects of dopamine in healthy men.
Details
Serval ID
serval:BIB_87C5B8735037
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thermogenic and metabolic effects of dopamine in healthy men.
Journal
Critical Care Medicine
ISSN
0090-3493 (Print)
ISSN-L
0090-3493
Publication state
Published
Issued date
1991
Volume
19
Number
8
Pages
1030-1036
Language
english
Abstract
OBJECTIVE: To assess the thermogenic response of dopamine at three different infusion rates and to analyze its effects on various biochemical variables.
DESIGN: Randomized sequential experimental treatment bracketed by control periods.
PATIENTS: Eight young healthy male volunteers with normal body weight (51 to 89 kg).
INTERVENTIONS: Three experimental periods during which dopamine was administered iv in a randomized order at rates of 2.5, 5, or 10 micrograms/kg.min with one preinfusion baseline and two recovery periods in between.
MEASUREMENTS AND MAIN RESULTS: A significant (p less than .01) increase in resting energy expenditure was observed in response to the two highest dopamine infusion rates (5 and 10 micrograms/kg.min), corresponding to 6% and 15% median increases, respectively, as compared with preinfusion values. At the lowest dopamine infusion rate, no variation in resting energy expenditure was observed. Dopamine induced a significant (p less than .01) increase in hyperglycemia at all three infusion rates, and, at the highest infusion rate, dopamine induced a significant (p less than .05) increase of plasma free fatty acid concentrations. Insulin plasma concentrations were significantly (p less than .05 to p less than 0.1) increased at the three dopamine infusion rates.
CONCLUSIONS: Dopamine infusion produces a dose-dependent thermogenic effect and induces various metabolic actions in man.
DESIGN: Randomized sequential experimental treatment bracketed by control periods.
PATIENTS: Eight young healthy male volunteers with normal body weight (51 to 89 kg).
INTERVENTIONS: Three experimental periods during which dopamine was administered iv in a randomized order at rates of 2.5, 5, or 10 micrograms/kg.min with one preinfusion baseline and two recovery periods in between.
MEASUREMENTS AND MAIN RESULTS: A significant (p less than .01) increase in resting energy expenditure was observed in response to the two highest dopamine infusion rates (5 and 10 micrograms/kg.min), corresponding to 6% and 15% median increases, respectively, as compared with preinfusion values. At the lowest dopamine infusion rate, no variation in resting energy expenditure was observed. Dopamine induced a significant (p less than .01) increase in hyperglycemia at all three infusion rates, and, at the highest infusion rate, dopamine induced a significant (p less than .05) increase of plasma free fatty acid concentrations. Insulin plasma concentrations were significantly (p less than .05 to p less than 0.1) increased at the three dopamine infusion rates.
CONCLUSIONS: Dopamine infusion produces a dose-dependent thermogenic effect and induces various metabolic actions in man.
Keywords
Adult, Blood Glucose/metabolism, Body Temperature/drug effects, Dopamine/administration & dosage, Dopamine/pharmacology, Dose-Response Relationship, Drug, Energy Metabolism/drug effects, Fatty Acids, Nonesterified/blood, Heart Rate/drug effects, Humans, Insulin/blood, Male
Pubmed
Web of science
Create date
21/01/2008 14:07
Last modification date
20/08/2019 15:47