Assessment of diesel exhaust particulate exposure and surface characteristics in association with levels of oxidative stress biomarkers

Details

Ressource 1Download: BIB_87B49EADDFCB.P001.pdf (184.09 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_87B49EADDFCB
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Assessment of diesel exhaust particulate exposure and surface characteristics in association with levels of oxidative stress biomarkers
Title of the conference
Biomedical imaging, CHUV Research Day, February 1, 2007
Author(s)
Setyan Ari, Sauvain Jean-Jacques, Riediker Michael, Rossi Michel, Guillemin Michel
Publisher
Université de Lausanne, Faculté de biologie et de médecine
Address
Lausanne
Publication state
Published
Issued date
2007
Pages
EHU-20, 34
Language
english
Notes
Type de document : Abstracts SAPHIRID:64521
Abstract
The increase of exposure to PM10 and PM2.5 (particulate matter with aerodynamic diameter smaller than 10 μm and 2.5 μm) has been found to be associated with a range of adverse health effects. Surface characteristics (chemical reactivity, surface area) are considered of prime importance to understand the mechanisms which lead to harmful effects. A hypothetical mechanism to explain these adverse effects of particulate matter is the ability of some components (organics, metal ions) adsorbed on these particles to generate reactive oxygen species (ROS), and thereby to cause oxidative stress in biological systems. ROS can attack almost any cellular structure, leading to the formation of a wide variety of degradation products which can be used as a biomarker of oxidative stress. The aim of the present research project is to demonstrate an association between the exposure to Diesel exhaust particulate (DEP) and the oxidative stress status. For that purpose, a survey is conducted in real occupational situations where workers are exposed to DEP (bus depots). Several biomarkers of oxidative stress have been determined either in urine or serum of volunteers, and levels will be discussed in relation to exposure variables. In order to bring some insight into the relation between the particulate surface characteristics and the formation of ROS by-products, different exposure variables have been considered:
- particulate number, distribution and surface (SMPS);
- particulate mass (gravimetry);
- elemental and organic carbon (coulometry);
- total adsorbed heavy metals (atomic absorption);
- surface functional groups present on particles (Knudsen flow reactor).
Keywords
Vehicle Emissions , Aerosols , Particulate Matter , Oxidative Stress , Reactive Oxygen Species , Biological Markers , Surface Properties , Occupational Exposure
Create date
07/04/2008 10:07
Last modification date
20/08/2019 14:46
Usage data